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Steiness E, Bille-Brahe NE, Hansen JF, et al. Reduced myocardial blood flow in acute and chronic digitalization. Acta Pharmacol Toxicol (Copenh). 1978;43(1):29-35doi: 10.1111/j.1600-0773.1978.tb02228.x.
Steiness, E., Bille-Brahe, N. E., Hansen, J. F., Lomholt, N., & Ring-Larsen, H. (1978). Reduced myocardial blood flow in acute and chronic digitalization. Acta pharmacologica et toxicologica, 43(1), 29-35. https://doi.org/10.1111/j.1600-0773.1978.tb02228.x
Steiness, E, et al. "Reduced myocardial blood flow in acute and chronic digitalization." Acta pharmacologica et toxicologica vol. 43,1 (1978): 29-35. doi: https://doi.org/10.1111/j.1600-0773.1978.tb02228.x
Steiness E, Bille-Brahe NE, Hansen JF, Lomholt N, Ring-Larsen H. Reduced myocardial blood flow in acute and chronic digitalization. Acta Pharmacol Toxicol (Copenh). 1978 Jul;43(1):29-35. doi: 10.1111/j.1600-0773.1978.tb02228.x. PMID: 707121.
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Acta Pharmacol Toxicol (Copenh). 1978 Jul;43(1):29-35. doi: 10.1111/j.1600-0773.1978.tb02228.x.

Reduced myocardial blood flow in acute and chronic digitalization.

Acta pharmacologica et toxicologica

E Steiness, N E Bille-Brahe, J F Hansen, N Lomholt, H Ring-Larsen

PMID: 707121 DOI: 10.1111/j.1600-0773.1978.tb02228.x

Abstract

The myocardial blood flow was measured by the 133Xenon disappearance curve from the left ventricular wall following an injection of 133Xenon in the left coronary artery in 8 dogs without digoxin pretreatment and in 8 chronically digitalized dogs. The myocardial blood flow was significantly less (30%) in the digitalized dogs than in the dogs without pretreatment. In the digitalized dogs as well as in those without pretreatment an intravenous injection of digoxin resulted in a further significant decrease of the myocardial blood flow of about 20% and a significant increase of the coronary vascular resistance. The reduced myocardial blood flow both during acute and chronic digitalization is beleived to be of clinical importance.

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