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Elsevier Science

Lancet. 1978 Feb 04;1(8058):230-3. doi: 10.1016/s0140-6736(78)90480-4.

Primary biliary cirrhosis and coeliac disease: an association?.

Lancet (London, England)

R F Logan, A Ferguson, N D Finlayson, D G Weir

PMID: 74661 DOI: 10.1016/s0140-6736(78)90480-4

Abstract

The association of primary biliary cirrhosis and coeliac disease, not previously reported, was observed in 4 patients. In each case, the two conditions were diagnosed simultaneously, and although symptoms were due to coeliac disease, initial investigation drew attention to the liver condition. All the patients responded to a gluten-free diet and remain well 2 years later. Primary biliary cirrhosis remains asymptomatic in 3 patients, but pruritus has developed in the 4th. The significance of this association is unclear and may merit formal study. Coeliac disease should be considered as a possible cause of unexplained weight loss in primary biliary cirrhosis.

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