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Nesterenko VV, Rozenshtraukh LV. Umen'shenie natrievoĭ provodimosti membrany kardiomiotsitov--prichina otritsatel'nogo inotropnogo deĭstviia khinidinopodobnykh antiaritmicheskikh sredstv. [Decreased sodium conductance of the cardiomyocyte membrane: the cause of the negative inotropic action of quinidine-like anti-arrhythmia agents]. Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1982;5(2):41-51
Nesterenko, V. V., & Rozenshtraukh, L. V. (1982). Umen'shenie natrievoĭ provodimosti membrany kardiomiotsitov--prichina otritsatel'nogo inotropnogo deĭstviia khinidinopodobnykh antiaritmicheskikh sredstv. [Decreased sodium conductance of the cardiomyocyte membrane: the cause of the negative inotropic action of quinidine-like anti-arrhythmia agents]. Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR, 5(2), 41-51.
Nesterenko, V V, and Rozenshtraukh, L V. "Umen'shenie natrievoĭ provodimosti membrany kardiomiotsitov--prichina otritsatel'nogo inotropnogo deĭstviia khinidinopodobnykh antiaritmicheskikh sredstv." [Decreased sodium conductance of the cardiomyocyte membrane: the cause of the negative inotropic action of quinidine-like anti-arrhythmia agents]. Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR vol. 5,2 (1982): 41-51.
Nesterenko VV, Rozenshtraukh LV. Umen'shenie natrievoĭ provodimosti membrany kardiomiotsitov--prichina otritsatel'nogo inotropnogo deĭstviia khinidinopodobnykh antiaritmicheskikh sredstv. [Decreased sodium conductance of the cardiomyocyte membrane: the cause of the negative inotropic action of quinidine-like anti-arrhythmia agents]. Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1982;5(2):41-51. Russian. PMID: 6291554.
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Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1982;5(2):41-51.

[Decreased sodium conductance of the cardiomyocyte membrane: the cause of the negative inotropic action of quinidine-like anti-arrhythmia agents].

Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR

[Article in Russian]
V V Nesterenko, L V Rozenshtraukh

PMID: 6291554

Abstract

The action of tetrodotoxin on the guinea-pig muscle caused a decrease in the maximum rate of action potential, which was accompanied by a negative inotropic effect. The magnitude of such an effect correlated well with the decrease of sodium permeability, measured by the maximum rate of depolarization (r = 0,995). The effect was enhanced under the action of veratrine and diminished under that of isoproterenol. It was suggested that the negative inotropic effect of tetrodotoxin was the result of the inhibition on Na-Ca exchange due to diminished intracellular Na+ concentration.

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