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Niemegeers CJ. Quelques aspects pharmacologiques des neuroleptiques. [Some pharmacological aspects of neuroleptics (author's transl)]. Encephale. 1981;7(3):215-24
Niemegeers, C. J. (1981). Quelques aspects pharmacologiques des neuroleptiques. [Some pharmacological aspects of neuroleptics (author's transl)]. L'Encephale, 7(3), 215-24.
Niemegeers, C J. "Quelques aspects pharmacologiques des neuroleptiques." [Some pharmacological aspects of neuroleptics (author's transl)]. L'Encephale vol. 7,3 (1981): 215-24.
Niemegeers CJ. Quelques aspects pharmacologiques des neuroleptiques. [Some pharmacological aspects of neuroleptics (author's transl)]. Encephale. 1981;7(3):215-24. French. PMID: 6116591.
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Encephale. 1981;7(3):215-24.

[Some pharmacological aspects of neuroleptics (author's transl)].

L'Encephale

[Article in French]
C J Niemegeers

PMID: 6116591

Abstract

Neuroleptics have several typical pharmacological properties in common. It is logical to assume that these common properties are based on a common biochemical mechanism of action: their postsynaptic dopamine receptor blocking activity, and that they are related to the clinical activities common to all neuroleptics: their antipsychotic activity and their extrapyramidal side-effect liability. Neuroleptics, to a different degree, may possess many other pharmacological properties as well: - antagonism of serotonin, noradrenaline, histamine, acetylcholine - not related to their antidopamine activity. These properties of different origin are probably responsible for the qualitative differences between neuroleptics that are observed in the clinic.

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