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Filer CW, Humphrey MJ, Jeffery DJ, et al. The metabolism of carfecillin in rat, dog and man. Xenobiotica. 1980;10(10):761-9doi: 10.3109/00498258009033804.
Filer, C. W., Humphrey, M. J., Jeffery, D. J., Jones, K. H., & Langley, P. F. (1980). The metabolism of carfecillin in rat, dog and man. Xenobiotica; the fate of foreign compounds in biological systems, 10(10), 761-9. https://doi.org/10.3109/00498258009033804
Filer, C W, et al. "The metabolism of carfecillin in rat, dog and man." Xenobiotica; the fate of foreign compounds in biological systems vol. 10,10 (1980): 761-9. doi: https://doi.org/10.3109/00498258009033804
Filer CW, Humphrey MJ, Jeffery DJ, Jones KH, Langley PF. The metabolism of carfecillin in rat, dog and man. Xenobiotica. 1980 Oct;10(10):761-9. doi: 10.3109/00498258009033804. PMID: 6256982.
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Xenobiotica. 1980 Oct;10(10):761-9. doi: 10.3109/00498258009033804.

The metabolism of carfecillin in rat, dog and man.

Xenobiotica; the fate of foreign compounds in biological systems

C W Filer, M J Humphrey, D J Jeffery, K H Jones, P F Langley

PMID: 6256982 DOI: 10.3109/00498258009033804

Abstract

1. The absorption of the phenol moiety of [phenol-14C]carfecillin following oral administration to rat, dog and man was extensive, since 95%, 73% and 99% of the administered radioactivity respectively was recovered in the urine. In contrast, less than half of the carbenicillin moiety of carfecillin was absorbed after oral administration, as judged by excretion studies using [carbenicillin-14C]carfecillin in intact and bile-duct cannulated animals. 2. The patterns of radiometabolites in the urines of rat, dog and man following single oral administration of [phenol-14C]carfecillin were determined by chromatography and radioassay. In two men, the majority of a dose was excreted as phenylsulphate (71%) and phenylglucuronide (16%) with the sulphate and glucuronic acid conjugates of quinol representing small amounts of the urinary radioactivity. Similar metabolic patterns were observed in the rat and dog following oral administration of either [14C]phenol or [phenol-14C]carfecillin, although some saturation of sulphate conjugation was apparent at the dose levels employed.

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