Zentralbl Allg Pathol. 1977;121(6):517-21.

[Multiple nodular hyperplasia of liver associated with oral contraceptives (author's transl)].

Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie

[Article in German]
G Roschlau

PMID: 607696

Abstract

Two cases of multiple nodular hyperplasia of liver in patients with intake or oral contraceptives for several years are described. In one case the tumours appeared simultaneously, in the other case succesively. Macroscopically the nodular hyperplasia was misdiagnosed as metastasis. Microscopially the nodes presented an intense inflammatory infiltration of the septa, in one case with tuberculoid granulomas. The lesions showed a marked vascularity. Extremely dilated sinusoids could be seen in the needle biopsy of the macroscopically unchanged liver, a phenomenon occasionally seen in cases treated with oral contraceptives.

Keywords: Biology; Case Studies; Chlormadinone Acetate--side effects; Contraception; Contraceptive Agents, Estrogen--side effects; Contraceptive Agents, Female--side effects; Contraceptive Agents, Progestin--side effects; Contraceptive Agents--side effects; Contraceptive Methods--side effects; Ethinyl Estradiol; Family Planning; Hepatic Effects--etiology; Histology; Mestranol--side effects; Norethindrone; Norethindrone Acetate; Oral Contraceptives, Combined; Oral Contraceptives--side effects; Physiology; Research Methodology; Studies

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Substances

• Contraceptives, Oral

MeSH terms

• Adult
• Chemical and Drug Induced Liver Injury*
• Contraceptives, Oral / adverse effects
• Female
• Humans
• Hyperplasia
• Liver / pathology
• Liver Diseases / pathology
• Time Factors

Publication Types

• Case Reports
• Journal Article