Ultrastructural and enzymatic development of fetal guinea pig heart.

Display options

Format

Share it on

Full text links

Am J Physiol. 1982 Jul;243(1):H87-93. doi: 10.1152/ajpheart.1982.243.1.H87.

Ultrastructural and enzymatic development of fetal guinea pig heart.

The American journal of physiology

T P Rolph, C T Jones, D Parry

PMID: 6211993 DOI: 10.1152/ajpheart.1982.243.1.H87

Abstract

The activities of some enzymes of glycolysis, the citric acid cycle, and amino acid metabolism have been measured in the fetal guinea pig heart over the last third of gestation and correlated with heart ultrastructural development. There is little change in glycolytic enzyme activity except for a two- to threefold increase in phosphofructokinase activity. Mitochondrial content and enzyme activities are low in the early fetal heart, and, although content is similar in the late fetus and adult, enzyme activities increase twofold postnatally, indicating fetal heart mitochondria are incompletely developed. The activities of aspartate and particularly alanine aminotransferase are low in the fetal heart. Over the last third of gestation the myofibrillar content of the fetal myocyte increases twofold to the adult value by term. Associated with this is a fourfold rise in myofibrillar and sarcoplasmic reticulum Ca2+-ATPase activity. Na+-K+-ATPase activity is similar in the late fetal and adult heart but one-third lower in the early fetal heart.

Cited by

Time Mating Guinea Pigs by Monitoring Changes to the Vaginal Membrane throughout the Estrus Cycle and with Ultrasound Confirmation.

Wilson RL, Lampe K, Matushewski BJ, Regnault TRH, Jones HN.
Methods Protoc. 2021 Aug 27;4(3). doi: 10.3390/mps4030058.
PMID: 34564304

Ultrastructural and enzymatic development of fetal guinea pig heart.

Abstract

Cited by

Substances

MeSH terms

Publication Types

LinkOut - more resources