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Springer

Eur J Clin Pharmacol. 1977 Nov 14;12(3):213-9. doi: 10.1007/BF00609864.

Dose dependent pharmacokinetics of prednisolone.

European journal of clinical pharmacology

M E Pickup, J R Lowe, P A Leatham, V M Rhind, V Wright, W W Downie

PMID: 590308 DOI: 10.1007/BF00609864

Abstract

The pharmacokinetics of prednisolone elimination have been studied in both arthritic patients and normal volunteers using tritiated prednisolone alone, and in conjunction with unlabelled prednisolone in doses of 0.15 mg-kg-1 and 0.3 mg-kg-1 body weight. With increasing dose there is prolongation of the plasma half-life and increase in the volume of distribution and plasma clearance of prednisolone. It is proposed that these changes in pharmacokinetic parameters may be associated with non-linear binding of the steroid to plasma proteins.

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