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Wünsch PH, Heine WD. Zur Wirkung von Flavonoiden an der Rattenleber bei chronischer Phalloidin-Vergiftung. Morphologische und klinisch-chemische Untersuchungen. [The effects of flavonoids on rat liver during chronic palloidin intoxication/Morphological and biochemical studies (author's transl)]. Arzneimittelforschung. 1979;29(10):1570-4
Wünsch, P. H., & Heine, W. D. (1979). Zur Wirkung von Flavonoiden an der Rattenleber bei chronischer Phalloidin-Vergiftung. Morphologische und klinisch-chemische Untersuchungen. [The effects of flavonoids on rat liver during chronic palloidin intoxication/Morphological and biochemical studies (author's transl)]. Arzneimittel-Forschung, 29(10), 1570-4.
Wünsch, P H, and Heine, W D. "Zur Wirkung von Flavonoiden an der Rattenleber bei chronischer Phalloidin-Vergiftung. Morphologische und klinisch-chemische Untersuchungen." [The effects of flavonoids on rat liver during chronic palloidin intoxication/Morphological and biochemical studies (author's transl)]. Arzneimittel-Forschung vol. 29,10 (1979): 1570-4.
Wünsch PH, Heine WD. Zur Wirkung von Flavonoiden an der Rattenleber bei chronischer Phalloidin-Vergiftung. Morphologische und klinisch-chemische Untersuchungen. [The effects of flavonoids on rat liver during chronic palloidin intoxication/Morphological and biochemical studies (author's transl)]. Arzneimittelforschung. 1979;29(10):1570-4. German. PMID: 583224.
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Arzneimittelforschung. 1979;29(10):1570-4.

[The effects of flavonoids on rat liver during chronic palloidin intoxication/Morphological and biochemical studies (author's transl)].

Arzneimittel-Forschung

[Article in German]
P H Wünsch, W D Heine

PMID: 583224

Abstract

Continuous intraperitoneal administration of phalloidin (0.5 mg/kg body weight/day) leads to an alteration of intracellular contractile acto-myosinfilaments in rat liver. The hepatocytes show an accumulation of fibrillar material with some loss of contractile function of the pericanalicular web. Biochemically an increase of serum transaminases and alkaline phosphatase occurs. Histochemically the liver exhibitis changes in the distribution of some hepatocellular enzymes. The influence of the flavonoid (+)-cyanidanol-3 on these phalloidin-induced lesions was studied by histochemical, immunofluorescence and biochemical methods. The results imply, that (+)-cyanidanol-3 is probably protecting the plasma membrane of hepatocytes and therefore reduces the entrance of phalloidin into the cytoplasm. In addition an increased activity of the reticuloendothelial system was observed, perhaps resulting from the flavonoid administration. Both effects could be discussed as mechanisms of flavonoid action in the liver.

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