Arzneimittelforschung. 1978;28(3):400-2.

Effects of diltiazem hydrochloride (CRD-401) on hepatic, superior mesenteric and femoral hemodynamics.

Arzneimittel-Forschung

H Ishikawa, A Matsushima, H Matsui, T Shindo, T Morifuji, M Okabayashi

PMID: 580747

Abstract

The effects of d-3-acetoxy-cis-2,3-dihydro-5-[2-(dimethylamino)ethyll-2-(p-methoxyphenyl)-1,5-benzothiazepine-4(5H)-one hydrochloride (diltiazem hydrochloride; CRD-401) on the hepatic, superior mesenteric and femoral arteries were investigated in dogs. The results obtained were as follows: 1. At an i.v. dose of 100 microgram/kg, CRD-401 lowered the mean aortic blood pressure (-5%). It also decreased the diastolic aortic blood pressure (-11%) but did not affect the systolic aortic blood pressure. 2. The mean aortic blood pressure decreased after injection of CRD-401, but the blood flows in the hepatic, superior mesneteric and femoral arteries increased to 33%, 31% and 17%, respectively, more than did the control values and the vascular resistances of these arteries decreased by 25%, 27% and 17%, respectively. The present study obviously demonstrates that CRD-401 has vasodilating action on the hepatic, superior mesenteric and femoral arteries.

Substances

• Benzazepines
• Diltiazem

MeSH terms

• Animals
• Benzazepines / pharmacology
• Diltiazem / pharmacology
• Dogs
• Femoral Artery / drug effects
• Hemodynamics / drug effects
• Liver Circulation / drug effects
• Mesenteric Arteries / drug effects
• Regional Blood Flow / drug effects
• Time Factors

Publication Types

• Journal Article