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de Teresa E, Vera A, Ortigosa J, et al. Interaction between anticoagulants and contraceptives: an unsuspected finding. Br Med J. 1979;2(6200):1260-1doi: 10.1136/bmj.2.6200.1260.
de Teresa, E., Vera, A., Ortigosa, J., Pulpon, L. A., Arus, A. P., & de Artaza, M. (1979). Interaction between anticoagulants and contraceptives: an unsuspected finding. British medical journal, 2(6200), 1260-1. https://doi.org/10.1136/bmj.2.6200.1260
de Teresa, E, et al. "Interaction between anticoagulants and contraceptives: an unsuspected finding." British medical journal vol. 2,6200 (1979): 1260-1. doi: https://doi.org/10.1136/bmj.2.6200.1260
de Teresa E, Vera A, Ortigosa J, Pulpon LA, Arus AP, de Artaza M. Interaction between anticoagulants and contraceptives: an unsuspected finding. Br Med J. 1979 Nov 17;2(6200):1260-1. doi: 10.1136/bmj.2.6200.1260. PMID: 519402; PMCID: PMC1596889.
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Br Med J. 1979 Nov 17;2(6200):1260-1. doi: 10.1136/bmj.2.6200.1260.

Interaction between anticoagulants and contraceptives: an unsuspected finding.

British medical journal

E de Teresa, A Vera, J Ortigosa, L A Pulpon, A P Arus, M de Artaza

PMID: 519402 PMCID: PMC1596889 DOI: 10.1136/bmj.2.6200.1260
Free PMC Article

Abstract

To assess the effects of oral contraceptives on anticoagulant treatment the prothrombin times of 12 patients were measured while they were taking both drugs simultaneously and while they were taking only anticoagulants. The mean prothrombin time ratio was significantly higher when patients were taking both drugs than when they were taking only anticoagulants and their doses of anticoagulant were significantly lower. During both periods most of the prothrombin values remained in the therapeutic range. These findings suggest that, contrary to the common belief that oral contraceptives diminish the effects of anticoagulants, contraceptives in fact potentiate the action of the anticoagulants.

Keywords: Biology; Blood Coagulation Effects; Clinical Research; Contraception; Contraceptive Methods; Diseases; Endocrine System; Enzyme Inhibitors; Enzymes And Enzyme Inhibitors; Estrogens; Family Planning; Heart Diseases; Hematological Effects; Hemic System; Hormones; Oral Contraceptives; Oral Contraceptives, Combined; Physiology; Research Methodology

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