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Berger M, Halban PA, Girardier L, et al. Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site. Diabetologia. 1979;17(2):97-9doi: 10.1007/BF01222209.
Berger, M., Halban, P. A., Girardier, L., Seydoux, J., Offord, R. E., & Renold, A. E. (1979). Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site. Diabetologia, 17(2), 97-9. https://doi.org/10.1007/BF01222209
Berger, M, et al. "Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site." Diabetologia vol. 17,2 (1979): 97-9. doi: https://doi.org/10.1007/BF01222209
Berger M, Halban PA, Girardier L, Seydoux J, Offord RE, Renold AE. Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site. Diabetologia. 1979 Aug;17(2):97-9. doi: 10.1007/BF01222209. PMID: 488572.
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Diabetologia. 1979 Aug;17(2):97-9. doi: 10.1007/BF01222209.

Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site.

Diabetologia

M Berger, P A Halban, L Girardier, J Seydoux, R E Offord, A E Renold

PMID: 488572 DOI: 10.1007/BF01222209

Abstract

The absorption of subcutaneously injected insulin was examined by injecting semisynthetic [3H] insulin in anaesthetized pigs and subsequently analysing the tissue excised from the injection site. Contrary to previously accepted views, a significant proportion of insulin was degraded at the injection site. The disappearance of intact [3H] insulin from the injection site followed a monoexponential function with a half-time of 59 min.

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References

  1. Biochem J. 1975 Nov;151(2):219-25 - PubMed
  2. Br Med J. 1978 Jan 28;1(6107):204-7 - PubMed
  3. Biochim Biophys Acta. 1972 Nov 24;286(1):136-45 - PubMed
  4. Biochem J. 1976 Nov 15;160(2):409-12 - PubMed
  5. Lancet. 1959 May 9;1(7080):964-7 - PubMed
  6. J Pediatr. 1964 Apr;64:547-51 - PubMed
  7. Diabetologia. 1978 Aug;15(2):133-40 - PubMed
  8. Am J Med Sci. 1962 Jan;243:49-56 - PubMed
  9. Acta Pharmacol Toxicol (Copenh). 1969;27 Suppl 2:1-84 - PubMed
  10. N Engl J Med. 1978 Jan 12;298(2):79-83 - PubMed
  11. J Clin Invest. 1959 Jul;38(7):1222-7 - PubMed
  12. Lancet. 1978 Aug 5;2(8084):283-5 - PubMed
  13. Diabetes. 1979 Jan;28 Suppl 1:53-7 - PubMed

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