Display options
Cite
Mihas AA, Foster MM, Barnes S, et al. Modification of D-galactosamine-induced liver injury in the rat by spironolactone. Pharmacology. 1979;18(5):235-40doi: 10.1159/000137258.
Mihas, A. A., Foster, M. M., Barnes, S., Mihas, T. A., Hirschowitz, B. I., & Spenney, J. G. (1979). Modification of D-galactosamine-induced liver injury in the rat by spironolactone. Pharmacology, 18(5), 235-40. https://doi.org/10.1159/000137258
Mihas, A A, et al. "Modification of D-galactosamine-induced liver injury in the rat by spironolactone." Pharmacology vol. 18,5 (1979): 235-40. doi: https://doi.org/10.1159/000137258
Mihas AA, Foster MM, Barnes S, Mihas TA, Hirschowitz BI, Spenney JG. Modification of D-galactosamine-induced liver injury in the rat by spironolactone. Pharmacology. 1979;18(5):235-40. doi: 10.1159/000137258. PMID: 482344.
Copy Download .nbib Format: NLM
Share it on
Full text links
S. Karger AG, Basel, Switzerland

Pharmacology. 1979;18(5):235-40. doi: 10.1159/000137258.

Modification of D-galactosamine-induced liver injury in the rat by spironolactone.

Pharmacology

A A Mihas, M M Foster, S Barnes, T A Mihas, B I Hirschowitz, J G Spenney

PMID: 482344 DOI: 10.1159/000137258

Abstract

Spironolactone, a competitive inhibitor of mineralocorticoid effects on the distal tubule of the kidney, has recently been found to have other metabolic effects. In these studies, spironolactone (200mg/kg intraperitoneally) for 3 days was found to have a marked protective effect against the hepatotoxic effect of D-galactosamine (275 mg/kg) in rats. Further progress in defining the mechanism of protection from D-galactosamine hepatic necrosis by spironolactone will require assessment of effects of spironolactone on uridine nucleotide metabolism.

Similar articles

Substances

MeSH terms

Publication Types

LinkOut - more resources