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Atypon Free PMC Article

Antimicrob Agents Chemother. 1979 Sep;16(3):362-5. doi: 10.1128/AAC.16.3.362.

Cochlear toxicity of butikacin (UK-18,892), a new semisynthetic aminoglycoside antibiotic, in guinea pigs.

Antimicrobial agents and chemotherapy

A J Carter

PMID: 507791 PMCID: PMC352861 DOI: 10.1128/AAC.16.3.362
Free PMC Article

Abstract

The cochleotoxic potential of butikacin (UK-18,892), a new semisynthetic aminoglycoside, has been evaluated in neonatal guinea pigs in comparison with amikacin, gentamicin, and kanamycin A. All compounds produced a dose-related increase of the mean threshold sound intensity required to elicit Preyer's reflex. Butikacin produced a similar level of cochlear toxicity to that of kanamycin A, but tended to be less cochleotoxic than amikacin. Gentamicin was the least cochleotoxic.

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