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Weber L, Meigel WN. Nature of collagen in dermatofibrosarcoma protuberans. Arch Dermatol Res. 1979;265(1):55-62doi: 10.1007/BF00412701.
Weber, L., & Meigel, W. N. (1979). Nature of collagen in dermatofibrosarcoma protuberans. Archives of dermatological research, 265(1), 55-62. https://doi.org/10.1007/BF00412701
Weber, L, and Meigel, W N. "Nature of collagen in dermatofibrosarcoma protuberans." Archives of dermatological research vol. 265,1 (1979): 55-62. doi: https://doi.org/10.1007/BF00412701
Weber L, Meigel WN. Nature of collagen in dermatofibrosarcoma protuberans. Arch Dermatol Res. 1979 May 29;265(1):55-62. doi: 10.1007/BF00412701. PMID: 475445.
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Arch Dermatol Res. 1979 May 29;265(1):55-62. doi: 10.1007/BF00412701.

Nature of collagen in dermatofibrosarcoma protuberans.

Archives of dermatological research

L Weber, W N Meigel

PMID: 475445 DOI: 10.1007/BF00412701

Abstract

The nature of collagen from 2 cases of dermatofibrosarcoma protuberans was studied. For this purpose, the tumor tissue was carefully separated from adjacent normal dermis. The collagen types comprised in the tumor were identified by CM-cellulose chromatographic and SDS-gel electrophoretic analysis of the component alpha-chains. Semiquantitative evaluation of the relative type III content was established by separation of the cyanogen bromide peptides on gels of 12% polyacrylamide in SDS. These studies showed that dermatofibrosarcoma protuberans contains alpha 1(I)-, alpha 2-, and alpha 1(III)-chains as well, and corresponding type I- and type III-related CNBr peptides. Comparing the collagen from dermatofibrosarcoma protuberans to that of normal skin, the relatively increased type III content in the case of dermatofibrosarcoma protuberans becomes apparent.

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