Zentralbl Allg Pathol. 1979;123(3):195-201.

[Liver biopsy findings after intake of oral contraceptives (author's transl)].

Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie

[Article in German]
K Mölleken

PMID: 473954

Abstract

115 liver biopsies of women who had taken oral contraceptives have been examined. In 106 of these case (68.4%) morphological modifications were found which may be considered as effects of the hormonal contraceptives. Dilations of the sinusoids with differently proliferated Kupffer cells were predominantly evident (73 cases). Medicamentally induced hepatitis (20 cases) and cholestatic hepatosis (5 cases) were considerably rare. The sinusoid ectasias may be understood as a consequence of liver damage by steroid hormones. The pathogenesis of the changes is unknown.

Keywords: Biology; Blood Coagulation Effects; Clinical Research; Hepatic Effects; Histology; Oral Contraceptives; Physiology; Research Methodology; Thromboembolism

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Substances

• Contraceptives, Oral

MeSH terms

• Adolescent
• Adult
• Biopsy, Needle
• Chemical and Drug Induced Liver Injury / etiology
• Cholestasis / chemically induced
• Contraceptives, Oral / pharmacology
• Female
• Humans
• Kupffer Cells / drug effects
• Liver / drug effects
• Liver / pathology
• Middle Aged

Publication Types

• Journal Article