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Chand N, DeRoth L, Eyre P. Relaxant response of goat trachea to 5-hydroxy-tryptamine mediated by D-tryptamine receptors. Br J Pharmacol. 1979;66(2):331-6doi: 10.1111/j.1476-5381.1979.tb13684.x.
Chand, N., DeRoth, L., & Eyre, P. (1979). Relaxant response of goat trachea to 5-hydroxy-tryptamine mediated by D-tryptamine receptors. British journal of pharmacology, 66(2), 331-6. https://doi.org/10.1111/j.1476-5381.1979.tb13684.x
Chand, N, et al. "Relaxant response of goat trachea to 5-hydroxy-tryptamine mediated by D-tryptamine receptors." British journal of pharmacology vol. 66,2 (1979): 331-6. doi: https://doi.org/10.1111/j.1476-5381.1979.tb13684.x
Chand N, DeRoth L, Eyre P. Relaxant response of goat trachea to 5-hydroxy-tryptamine mediated by D-tryptamine receptors. Br J Pharmacol. 1979 Jun;66(2):331-6. doi: 10.1111/j.1476-5381.1979.tb13684.x. PMID: 465888; PMCID: PMC2043619.
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Br J Pharmacol. 1979 Jun;66(2):331-6. doi: 10.1111/j.1476-5381.1979.tb13684.x.

Relaxant response of goat trachea to 5-hydroxy-tryptamine mediated by D-tryptamine receptors.

British journal of pharmacology

N Chand, L DeRoth, P Eyre

PMID: 465888 PMCID: PMC2043619 DOI: 10.1111/j.1476-5381.1979.tb13684.x
Free PMC Article

Abstract

1 Goat isolated trachea contracted in response to carbachol, histamine and 2-pyridylethylamine (an H(1)-receptor agonist) and relaxed after application of isoprenaline. 5-hydroxytryptamine (5-HT) and phenylephrine.2 Mepyramine, a selective H(1)-receptor antagonist, blocked histamine- and 2-pyridylethylamine-induced contractions. In high doses it also exhibited some nonspecific antagonism to carbachol. After H(1)-receptor blockade, 4-methylhistamine and dimaprit (specific H(2)-agonists) relaxed the carbachol-contracted trachea.3 Propranolol, a beta-adrenoceptor blocker, antagonized relaxation in response to isoprenaline and phenylephrine. In high doses, it produced a reversal of the phenylephrine response.4 Indomethacin enhanced contractions in response to carbachol and histamine.5 Relaxation to 5-HT was not affected by propranolol, indomethacin, metiamide or cimetidine (H(2)-blockers). These findings appear to exclude the involvement of adrenergic, prostaglandinergic and H(2)-histaminergic mechanisms in the mediation of this response.6 Atropine potentiated 5-HT-induced relaxations. This suggests the participation of a ;masked' excitatory cholinergic mechanism.7 Methysergide, dibenamine and dibenzyline selectively antagonized or reversed 5-HT-induced relaxation. Dibenamine and dibenzyline enhanced relaxations to isoprenaline.8 This investigation showed (i) a relaxant response of goat trachea to 5-HT, mediated via D-muscular tryptamine receptors; (ii) a small population of excitatory M-neuronal tryptamine and alpha-adrenoceptors; and (iii) predominance of H(1)-histamine receptors in the goat trachea.

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