Display options
Share it on
Full text links
Silverchair Information Systems Free PMC Article

Biochem J. 1973 Sep;136(1):135-45. doi: 10.1042/bj1360135.

The stereochemistry of hydrogen elimination from C-7 during biosynthesis of ecdysones in insects and plants.

The Biochemical journal

I F Cook, J G Lloyd-Jones, H H Rees, T W Goodwin

PMID: 4772621 PMCID: PMC1165933 DOI: 10.1042/bj1360135
Free PMC Article


1. [7alpha-(3)H(1)]- and [7beta-(3)H(1)]-Cholesterol were synthesized by a modified method. 2. The stereochemistry of Delta(7)-bond formation during ecdysone and ecdysterone biosynthesis in the insect, Calliphora erythrocephala and the plants, Taxus baccata and Polypodium vulgare was investigated by using [4-(14)C,7alpha-(3)H(1)]cholesterol and [4-(14)C,7beta-(3)H(1)]cholesterol. 3. In each case, the 7beta hydrogen was stereospecifically eliminated. 4. The possible significance of the results is discussed in relation to double-bond formation in other systems and the stage at which the Delta(7) bond is introduced during ecdysone biosynthesis.

Similar articles

Show all 88 similar articles

Cited by


  1. Eur J Biochem. 1971 Aug 16;21(3):428-32 - PubMed
  2. Pure Appl Chem. 1971;25(1):167-95 - PubMed
  3. J Biol Chem. 1970 Apr 10;245(7):1682-7 - PubMed
  4. Biochem J. 1969 Dec;115(4):857-8 - PubMed
  5. Biochem J. 1967 Dec;105(3):1187-94 - PubMed
  6. Hoppe Seylers Z Physiol Chem. 1963 Mar;331:289-300 - PubMed
  7. Biochem J. 1968 Feb;106(4):803-10 - PubMed
  8. Biochem J. 1970 Feb;116(3):337-9 - PubMed
  9. J Biol Chem. 1963 Jun;238:1966-72 - PubMed
  10. Proc R Soc Lond B Biol Sci. 1972 Feb 15;180(1059):203-21 - PubMed
  11. Eur J Biochem. 1972 May;27(1):10-22 - PubMed


MeSH terms

Publication Types

LinkOut - more resources