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Elsevier Science

Lancet. 1977 Aug 20;2(8034):367-9. doi: 10.1016/s0140-6736(77)90301-4.

Dissolution of cholesterol gallstones by ursodeoxycholic acid.

Lancet (London, England)

S Nakagawa, I Makino, T Ishizaki, I Dohi

PMID: 70585 DOI: 10.1016/s0140-6736(77)90301-4


44 patients with radiolucent gallstones in gallbladders visible on cholecystography were randomly alloted to three treatment groups: ursodeoxycholic acid (600 mg/day), ursodeoxycholic acid (150 mg/day), a placebo. At the end of six months' treatment, cholecystograms of all the patients were interpreted by radiologists who were not aware of the treatment. Dissolution of gallstones occurred in 8 (26%) of the 31 patients treated with ursodeoxycholic acid, but not in the placebo group. Ursodeoxycholic acid had no hepatotoxicity, as assessed by standard liver-function tests. These results indicate that ursodeoxycholic acid, the 7beta epimer of chenodeoxycholic acid, is effective in the dissolution of cholesterol gallstones.

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