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Roda E, Roda A, Sama C, et al. Effect of ursodeoxycholic acid administration on biliary lipid composition and bile acid kinetics in cholesterol gallstone patients. Dig Dis Sci. 1979;24(2):123-8doi: 10.1007/BF01324739.
Roda, E., Roda, A., Sama, C., Festi, D., Mazzella, G., Aldini, R., & Barbara, L. (1979). Effect of ursodeoxycholic acid administration on biliary lipid composition and bile acid kinetics in cholesterol gallstone patients. Digestive diseases and sciences, 24(2), 123-8. https://doi.org/10.1007/BF01324739
Roda, E, et al. "Effect of ursodeoxycholic acid administration on biliary lipid composition and bile acid kinetics in cholesterol gallstone patients." Digestive diseases and sciences vol. 24,2 (1979): 123-8. doi: https://doi.org/10.1007/BF01324739
Roda E, Roda A, Sama C, Festi D, Mazzella G, Aldini R, Barbara L. Effect of ursodeoxycholic acid administration on biliary lipid composition and bile acid kinetics in cholesterol gallstone patients. Dig Dis Sci. 1979 Feb;24(2):123-8. doi: 10.1007/BF01324739. PMID: 428300.
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Dig Dis Sci. 1979 Feb;24(2):123-8. doi: 10.1007/BF01324739.

Effect of ursodeoxycholic acid administration on biliary lipid composition and bile acid kinetics in cholesterol gallstone patients.

Digestive diseases and sciences

E Roda, A Roda, C Sama, D Festi, G Mazzella, R Aldini, L Barbara

PMID: 428300 DOI: 10.1007/BF01324739

Abstract

The effect of ursodeoxycholic acid (UDCA) on bile lipid composition and bile acid kinetics was evaluated in seven cholesterol gallstone patients following one month of UDCA administration (12 mg/kg/day). UDCA administration induces a significant reduction in the cholesterol saturation index (SI). After UDCA treatment, UDCA becomes the predominant biliary bile acid while chenodeoxycholic, cholic, and deoxycholic acid are significantly reduced. UDCA pool significantly increases, and chenodeoxycholic, cholic, and total bile acid pools significantly decrease. The reduction in bile lithogenicity during UDCA administration suggests that UDCA may be useful for cholesterol gallstone treatment in man.

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