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Laws ER, Piepgras DG, Randall RV, et al. Neurosurgical management of acromegaly. Results in 82 patients treated between 1972 and 1977. J Neurosurg. 1979;50(4):454-61doi: 10.3171/jns.1979.50.4.0454.
Laws, E. R., Piepgras, D. G., Randall, R. V., & Abboud, C. F. (1979). Neurosurgical management of acromegaly. Results in 82 patients treated between 1972 and 1977. Journal of neurosurgery, 50(4), 454-61. https://doi.org/10.3171/jns.1979.50.4.0454
Laws, E R, et al. "Neurosurgical management of acromegaly. Results in 82 patients treated between 1972 and 1977." Journal of neurosurgery vol. 50,4 (1979): 454-61. doi: https://doi.org/10.3171/jns.1979.50.4.0454
Laws ER, Piepgras DG, Randall RV, Abboud CF. Neurosurgical management of acromegaly. Results in 82 patients treated between 1972 and 1977. J Neurosurg. 1979 Apr;50(4):454-61. doi: 10.3171/jns.1979.50.4.0454. PMID: 423000.
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J Neurosurg. 1979 Apr;50(4):454-61. doi: 10.3171/jns.1979.50.4.0454.

Neurosurgical management of acromegaly. Results in 82 patients treated between 1972 and 1977.

Journal of neurosurgery

E R Laws, D G Piepgras, R V Randall, C F Abboud

PMID: 423000 DOI: 10.3171/jns.1979.50.4.0454

Abstract

A consecutive series of 82 acromegalic patients who underwent transsphenoidal surgery during a 5-year period is presented. Preoperative and postoperative values for human growth hormone (HGH) were available in 80 cases. Microadenomas were present in 18 patients with a mean preoperative HGH value of 25.2 ng/ml, diffuse adenomas in 39 patients with mean of 53.8 ng/ml, and invasive adenomas in 25 with mean of 68.0 ng/ml. There was no operative mortality. The results reflected the classification of the tumors, with apparent cures accomplished in 87.5% of previously untreated patients with microadenoma, all of whom had anterior pituitary function preserved. The percentages of apparent cures in cases of diffuse adenoma (68%) and invasive adenoma (54%) were much less satisfactory. Transsphenoidal microsurgery is capable of achieving good results, particularly in patients with microadenoma.

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