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Croce CM, Girardi AJ, Koprowski H. Assignment of the T-antigen gene of simian virus 40 to human chromosome C-7. Proc Natl Acad Sci U S A. 1973;70(12):3617-20doi: 10.1073/pnas.70.12.3617.
Croce, C. M., Girardi, A. J., & Koprowski, H. (1973). Assignment of the T-antigen gene of simian virus 40 to human chromosome C-7. Proceedings of the National Academy of Sciences of the United States of America, 70(12), 3617-20. https://doi.org/10.1073/pnas.70.12.3617
Croce, C M, et al. "Assignment of the T-antigen gene of simian virus 40 to human chromosome C-7." Proceedings of the National Academy of Sciences of the United States of America vol. 70,12 (1973): 3617-20. doi: https://doi.org/10.1073/pnas.70.12.3617
Croce CM, Girardi AJ, Koprowski H. Assignment of the T-antigen gene of simian virus 40 to human chromosome C-7. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3617-20. doi: 10.1073/pnas.70.12.3617. PMID: 4357883; PMCID: PMC427292.
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Proc Natl Acad Sci U S A. 1973 Dec;70(12):3617-20. doi: 10.1073/pnas.70.12.3617.

Assignment of the T-antigen gene of simian virus 40 to human chromosome C-7.

Proceedings of the National Academy of Sciences of the United States of America

C M Croce, A J Girardi, H Koprowski

PMID: 4357883 PMCID: PMC427292 DOI: 10.1073/pnas.70.12.3617
Free PMC Article

Abstract

Hybrid cell clones between mouse cells deficient in thymidine kinase (EC 2.7.1.21) and two different human cell lines transformed by simian virus 40 (SV40) and deficient in hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) were examined for SV40 tumor (T) antigen(s). Concordant segregation of the gene(s) for SV40 T antigen and human chromosome C-7 was observed in these hybrids. The human chromosome C-7 which contains the gene(s) for SV40 T antigen is preferentially retained by the majority of the hybrid clones tested. When hybrid clones positive and negative for SV40 T antigen, derived from the fusion of SV40-transformed Lesch-Nyhan fibroblasts with mouse cells, were fused with CV-1 permissive cells, SV40-specific V antigen was observed only in the cultures derived from fusion of the hybrid clones positive for T antigen. This result indicates a linkage relationship between human chromosome C-7, SV40 T-antigen gene(s), and SV40 genome(s) integrated in the human transformed cells.

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