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Ward AM, Underwood JC. Alpha1 antitrypsin deficiency and liver disease in childhood: genetic, immunochemical, histological, and ultrastructural diagnosis. J Clin Pathol. 1974;27(6):467-72
Ward, A. M., & Underwood, J. C. (1974). Alpha1 antitrypsin deficiency and liver disease in childhood: genetic, immunochemical, histological, and ultrastructural diagnosis. Journal of clinical pathology, 27(6), 467-72.
Ward, A M, and Underwood, J C. "Alpha1 antitrypsin deficiency and liver disease in childhood: genetic, immunochemical, histological, and ultrastructural diagnosis." Journal of clinical pathology vol. 27,6 (1974): 467-72.
Ward AM, Underwood JC. Alpha1 antitrypsin deficiency and liver disease in childhood: genetic, immunochemical, histological, and ultrastructural diagnosis. J Clin Pathol. 1974 Jun;27(6):467-72. PMID: 4212921; PMCID: PMC478157.
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J Clin Pathol. 1974 Jun;27(6):467-72.

Alpha1 antitrypsin deficiency and liver disease in childhood: genetic, immunochemical, histological, and ultrastructural diagnosis.

Journal of clinical pathology

A M Ward, J C Underwood

PMID: 4212921 PMCID: PMC478157
Free PMC Article

Abstract

alpha(1) Antitrypsin deficiency is a significant factor in the pathogenesis of neonatal cholestasis and progressive juvenile cirrhosis. The diagnosis may be suggested by the liver biopsy appearances and confirmed by immunochemical analysis of the serum. Genetic counselling of affected families is of importance, as medical treatment is ineffective at the present time.

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