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Tong GL, Lien EJ. Biotransformation of drugs: quantitative structure-activity relationships for barbiturates, tertiary amines, and substituted imidazoles. J Pharm Sci. 1976;65(11):1651-4doi: 10.1002/jps.2600651122.
Tong, G. L., & Lien, E. J. (1976). Biotransformation of drugs: quantitative structure-activity relationships for barbiturates, tertiary amines, and substituted imidazoles. Journal of pharmaceutical sciences, 65(11), 1651-4. https://doi.org/10.1002/jps.2600651122
Tong, G L, and Lien, E J. "Biotransformation of drugs: quantitative structure-activity relationships for barbiturates, tertiary amines, and substituted imidazoles." Journal of pharmaceutical sciences vol. 65,11 (1976): 1651-4. doi: https://doi.org/10.1002/jps.2600651122
Tong GL, Lien EJ. Biotransformation of drugs: quantitative structure-activity relationships for barbiturates, tertiary amines, and substituted imidazoles. J Pharm Sci. 1976 Nov;65(11):1651-4. doi: 10.1002/jps.2600651122. PMID: 11333.
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Elsevier Science

J Pharm Sci. 1976 Nov;65(11):1651-4. doi: 10.1002/jps.2600651122.

Biotransformation of drugs: quantitative structure-activity relationships for barbiturates, tertiary amines, and substituted imidazoles.

Journal of pharmaceutical sciences

G L Tong, E J Lien

PMID: 11333 DOI: 10.1002/jps.2600651122

Abstract

When using free energy-related physicochemical parameters, stimulation of NADPH oxidation by barbiturates and the N-oxidation of tertiary amines was found to be primarily dependent upon the lipophilic character of the substrates as measured by log P, where P is the partition coefficient from either 1-octanol-water or corn oil-water solvent systems. In contrast, the inhibition of epoxidation of aldrin by a series of substituted imidazoles appears to be much more dependent on electronic (sigma) and steric (Es) effects of the inhibitors.

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