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van Uigen AJ, van Dijk JE, Koch CA, et al. Freeze fracture morphology of thyroid tight junctions in goats with different thyrotropin stimulation. Endocrinology. 1985;117(1):114-8doi: 10.1210/endo-117-1-114.
van Uigen, A. J., van Dijk, J. E., Koch, C. A., & de Vijlder, J. J. (1985). Freeze fracture morphology of thyroid tight junctions in goats with different thyrotropin stimulation. Endocrinology, 117(1), 114-8. https://doi.org/10.1210/endo-117-1-114
van Uigen, A J, et al. "Freeze fracture morphology of thyroid tight junctions in goats with different thyrotropin stimulation." Endocrinology vol. 117,1 (1985): 114-8. doi: https://doi.org/10.1210/endo-117-1-114
van Uigen AJ, van Dijk JE, Koch CA, de Vijlder JJ. Freeze fracture morphology of thyroid tight junctions in goats with different thyrotropin stimulation. Endocrinology. 1985 Jul;117(1):114-8. doi: 10.1210/endo-117-1-114. PMID: 4006860.
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Endocrinology. 1985 Jul;117(1):114-8. doi: 10.1210/endo-117-1-114.

Freeze fracture morphology of thyroid tight junctions in goats with different thyrotropin stimulation.

Endocrinology

A J van Uigen, J E van Dijk, C A Koch, J J de Vijlder

PMID: 4006860 DOI: 10.1210/endo-117-1-114

Abstract

In the thyroid follicles and blood of goats with congenital hypothyroidism and goiter, abnormal iodoproteins (e.g. iodoalbumin) are found. To study the mechanism involved in the passage of these proteins between the follicles and the blood, the morphology of tight junctions in goiters and normal thyroids of goats was studied by means of freeze fracturing. The T4 and TSH levels of 16 goats were measured by RIA. Based on the TSH levels, the goats could be divided into three groups: a euthyroid group of eight goats with TSH levels between 28 and 55 mU/liter, a hypothyroid group of six goats with TSH levels higher than 199 mU/liter, and an intermediary group of two goats with TSH levels of 120 and 124 mU/liter, respectively. The euthyroid and intermediate animals had normal T4 levels (less than 49 nmol/liter), except for three newborn goats, which had T4 levels above 250 nmol/liter. The hypothyroid goats had T4 levels below 43 nmol/liter. The mean numbers of strands composing the tight junctions were negatively correlated with TSH levels. Hence, the tight junctions of the glands of hypothyroid goats are narrower and are composed of fewer strands than those of normal thyroids. This reduction in tight junction complexity may provide an explanation for the leakage of proteins into the follicles of goitrous glands.

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