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Tripathi A, Singh M. Type B atrial receptor discharge increases on opening a nonhypotensive arteriovenous shunt in the dog. Proc Soc Exp Biol Med. 1985;178(3):426-31doi: 10.3181/00379727-178-42027.
Tripathi, A., & Singh, M. (1985). Type B atrial receptor discharge increases on opening a nonhypotensive arteriovenous shunt in the dog. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 178(3), 426-31. https://doi.org/10.3181/00379727-178-42027
Tripathi, A, and Singh, M. "Type B atrial receptor discharge increases on opening a nonhypotensive arteriovenous shunt in the dog." Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) vol. 178,3 (1985): 426-31. doi: https://doi.org/10.3181/00379727-178-42027
Tripathi A, Singh M. Type B atrial receptor discharge increases on opening a nonhypotensive arteriovenous shunt in the dog. Proc Soc Exp Biol Med. 1985 Mar;178(3):426-31. doi: 10.3181/00379727-178-42027. PMID: 3975229.
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Proc Soc Exp Biol Med. 1985 Mar;178(3):426-31. doi: 10.3181/00379727-178-42027.

Type B atrial receptor discharge increases on opening a nonhypotensive arteriovenous shunt in the dog.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

A Tripathi, M Singh

PMID: 3975229 DOI: 10.3181/00379727-178-42027

Abstract

A vagovagal cardioacceleratory reflex is activated when an arteriovenous (a-v) shunt is opened in the dog. However, the receptors which initiate this reflex have not been localized. Type B atrial receptor excitation was considered to be a major component of this reflex. The effect of opening a femoral nonhypotensive a-v shunt (i.e., shunt open plus infusion of blood to compensate for the resultant fall in mean arterial and pulse pressure) on type B atrial receptor discharge and heart rate was therefore studied in seven anesthetized, artifically ventilated dogs with beta-adrenergic blockade. Right atrial and aortic blood pressures, heart rate, and type B atrial receptor discharge was studied before and after opening a femoral a-v shunt. On opening the a-v shunt there was a significant increase (44%) in the average activity of type B atrial receptors and a small, but significant (6.8%) increase in heart rate. A significant linear positive correlation was observed between the change in activity of type B atrial receptors and the shunt flow. The results suggest that type B atrial receptors may be one of the receptor groups that initiate this vagovagal reflex.

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