Display options
Cite
Marlin GE, Turner P. Comparison of the beta2-adrenoceptor selectivity of rimiterol, salbutamol and isoprenaline by the intravenous route in man. Br J Clin Pharmacol. 1975;2(1):41-8doi: 10.1111/j.1365-2125.1975.tb00470.x.
Marlin, G. E., & Turner, P. (1975). Comparison of the beta2-adrenoceptor selectivity of rimiterol, salbutamol and isoprenaline by the intravenous route in man. British journal of clinical pharmacology, 2(1), 41-8. https://doi.org/10.1111/j.1365-2125.1975.tb00470.x
Marlin, G E, and Turner, P. "Comparison of the beta2-adrenoceptor selectivity of rimiterol, salbutamol and isoprenaline by the intravenous route in man." British journal of clinical pharmacology vol. 2,1 (1975): 41-8. doi: https://doi.org/10.1111/j.1365-2125.1975.tb00470.x
Marlin GE, Turner P. Comparison of the beta2-adrenoceptor selectivity of rimiterol, salbutamol and isoprenaline by the intravenous route in man. Br J Clin Pharmacol. 1975 Feb;2(1):41-8. doi: 10.1111/j.1365-2125.1975.tb00470.x. PMID: 10940; PMCID: PMC1402492.
Copy Download .nbib Format: NLM
Share it on
Full text links
Wiley Free PMC Article

Br J Clin Pharmacol. 1975 Feb;2(1):41-8. doi: 10.1111/j.1365-2125.1975.tb00470.x.

Comparison of the beta2-adrenoceptor selectivity of rimiterol, salbutamol and isoprenaline by the intravenous route in man.

British journal of clinical pharmacology

G E Marlin, P Turner

PMID: 10940 PMCID: PMC1402492 DOI: 10.1111/j.1365-2125.1975.tb00470.x
Free PMC Article

Abstract

1 The bronchodilating efficacy and the degree of beta2-adrenoceptor selectivity of rimiterol, salbutamol and isoprenaline were determined in seven subjects who exhibited histamine-induced bronchoconstriction. 2 Rimiterol, 0.5 (high dose) and 0.05 (low dose) mug kg-1 min-1, salbutamol, 0.3 and 0.03 mug kg-1 min-1, isoprenaline, 0.05 and 0.005 mug kg-1 min-1 and placebo were administered by a single intravenous injection over 6 min, and the protection against histamine-induced bronchoconstriction, changes in heart rate, pulse pressure and skeletal muscle tremor were measured. 3 Rimiterol (98%), salbutamol (96%) and isoprenaline (69%) protected against histamine-induced bronchoconstriction. For these ventilatory responses, there was a heart rate increase of 31.9, 24.7 and 44.3 beats/min for rimiterol, salbutamol and isoprenaline respectively. The three drugs produced similar increases in pulse pressure and tremor. 4 Significant dose-responses were obtained for all the parameters with each drug. 5 Isoprenaline was approximately 7 and 5 times as potent as rimiterol and salbutamol respectively in bronchodilator action when equimolar doses were compared. Similarly, isoprenaline was approximately 14 and 10 times as potent in increasing the heart rate as rimiterol and salbutamol respectively. 6 Rimiterol, a new beta-adrenoceptor stimulating drug, is an effective bronchodilator and has similar beta2-adrenoceptor selectivity to salbutamol when administered intravenously. The relative potencies and degrees of beta2-adrenoceptor selectivity of these drugs depend partly on their route of administration.

Similar articles

References

  1. Br J Dis Chest. 1972 Jan;66(1):21-6 - PubMed
  2. Br J Pharmacol. 1974 Apr;50(4):587-91 - PubMed
  3. Br Med J. 1974 May 4;2(5913):250-2 - PubMed
  4. Br J Pharmacol. 1972 Nov;46(3):458-72 - PubMed
  5. Eur J Clin Pharmacol. 1974 Jul 26;7(4):263-8 - PubMed
  6. Br J Dis Chest. 1969 Jul;63(3):165-74 - PubMed
  7. Postgrad Med J. 1971 Mar;47:Suppl:115-8 - PubMed
  8. J Clin Pharmacol New Drugs. 1971 Jul-Aug;11(4):280-7 - PubMed
  9. Clin Pharmacol Ther. 1972 Nov-Dec;13(6):861-7 - PubMed
  10. Br J Pharmacol. 1972 Aug;45(4):574-83 - PubMed
  11. Br J Dis Chest. 1971 Jan;65(1):21-38 - PubMed
  12. Br J Pharmacol. 1971 Nov;43(3):624-38 - PubMed
  13. Br Med J. 1970 Jan 10;1(5688):65-70 - PubMed
  14. Br J Dis Chest. 1970 Jan;64(1):37-45 - PubMed
  15. Br J Dis Chest. 1970 Jan;64(1):46-54 - PubMed
  16. Postgrad Med J. 1971 Mar;47:Suppl:44-6 - PubMed
  17. Postgrad Med J. 1971 Mar;47:Suppl:92-9 - PubMed
  18. Br J Pharmacol. 1969 Jan;35(1):141-51 - PubMed
  19. Clin Sci. 1967 Aug;33(1):53-65 - PubMed
  20. Thorax. 1973 Mar;28(2):124-8 - PubMed
  21. Br J Pharmacol. 1973 Sep;49(1):153P-154P - PubMed
  22. Pharmacol Rev. 1969 Mar;21(1):27-72 - PubMed
  23. Br J Pharmacol Chemother. 1968 Jan;32(1):201-18 - PubMed
  24. Br J Pharmacol. 1970 Jan;38(1):37-49 - PubMed
  25. Br Med J. 1971 Mar 20;1(5750):633-6 - PubMed
  26. Br Med J. 1971 Mar 20;1(5750):637-9 - PubMed
  27. J Pharm Pharmacol. 1971 Aug;23(8):633-4 - PubMed
  28. Arch Int Pharmacodyn Ther. 1971 Dec;194(2):334-45 - PubMed
  29. J Clin Pharmacol New Drugs. 1972 Apr;12(4):158-68 - PubMed
  30. Int Z Klin Pharmakol Ther Toxikol. 1971 Dec;5(3):293-6 - PubMed
  31. Scand J Respir Dis. 1972;53(5):302-13 - PubMed
  32. Eur J Pharmacol. 1971 Oct;16(2):136-41 - PubMed
  33. Am Rev Respir Dis. 1973 Sep;108(3):501-5 - PubMed

Substances

MeSH terms

Publication Types

LinkOut - more resources