Pathol Biol (Paris). 1985 Jun;33(5):581-5.

[Computerized analysis of activity profiles of beta-lactams].

Pathologie-biologie

[Article in French]
J S Pitton, J L Philippin, P Fournier

PMID: 3937131

Abstract

This study was designed to compare the in vitro activities of recent cephalosporins and other beta-lactams. One of our objectives was to determine whether the microbiologist could use a single cephalosporin for routine antibiotic sensitivity testing. All the strains studied were recovered from outpatients. Sensitivity and/or resistance were evaluated by MIC determination, according to a program developed in our laboratory, using a personal computer. Using special programs, patterns of activities of beta-lactams were determined quantitatively and graphically for each bacterial strain tested. For most strains ceftriaxone, and to a lesser extent moxalactam and cefoperazone, exhibited greater antibacterial activity than the other beta-lactams, except against group D streptococci. For Enterobacteriaceae, cefadroxil is satisfactory in screening for in vitro activity of cephalosporins.

Substances

• Anti-Bacterial Agents
• Cephalosporins

MeSH terms

• Anti-Bacterial Agents / pharmacology
• Bacteria / drug effects
• Cephalosporins / pharmacology
• Computers
• Drug Resistance, Microbial
• Enterobacteriaceae / drug effects
• Enterococcus faecalis / drug effects
• Microbial Sensitivity Tests
• Pseudomonas aeruginosa / drug effects
• Staphylococcus aureus / drug effects
• Streptococcus / drug effects

Publication Types

• Comparative Study
• Journal Article

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