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Hach V, Bergmann L, Scharrer I, et al. Chronic thrombocytopenia in an immunodeficient patient with hemophilia A. Blut. 1985;50(5):293-8doi: 10.1007/BF00319755.
Hach, V., Bergmann, L., Scharrer, I., Mitrou, P., & Mueller-Eckhardt, C. (1985). Chronic thrombocytopenia in an immunodeficient patient with hemophilia A. Blut, 50(5), 293-8. https://doi.org/10.1007/BF00319755
Hach, V, et al. "Chronic thrombocytopenia in an immunodeficient patient with hemophilia A." Blut vol. 50,5 (1985): 293-8. doi: https://doi.org/10.1007/BF00319755
Hach V, Bergmann L, Scharrer I, Mitrou P, Mueller-Eckhardt C. Chronic thrombocytopenia in an immunodeficient patient with hemophilia A. Blut. 1985 May;50(5):293-8. doi: 10.1007/BF00319755. PMID: 3922459.
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Blut. 1985 May;50(5):293-8. doi: 10.1007/BF00319755.

Chronic thrombocytopenia in an immunodeficient patient with hemophilia A.

Blut

V Hach, L Bergmann, I Scharrer, P Mitrou, C Mueller-Eckhardt

PMID: 3922459 DOI: 10.1007/BF00319755

Abstract

Coincident hemophilia and idiopathic thrombocytopenia has been rarely observed. We report here on a young man with severe hemophilia A who was treated with concentrates of lyophilized antihemophilic factor for several years before he developed thrombocytopenia. An isolated thrombocytopenia coincident with reduced platelet survival, ample megakaryocytes in the bone marrow, elevated platelet-associated IgG, as well as remission after treatment with prednisone and splenectomy, suggest the idiopathic form of thrombocytopenia. In addition, defects in cellular immunity became obvious. A causal relationship between the application of blood-derived products and the development of the platelet disorder as well as the impairment of the T-cell system remain to be demonstrated.

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