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Kligerman AD, Campbell JA, Erexson GL, et al. Sister chromatid exchange analysis in lung and peripheral blood lymphocytes of mice exposed to methyl isocyanate by inhalation. Environ Mutagen. 1987;9(1):29-36doi: 10.1002/em.2860090105.
Kligerman, A. D., Campbell, J. A., Erexson, G. L., Allen, J. W., & Shelby, M. D. (1987). Sister chromatid exchange analysis in lung and peripheral blood lymphocytes of mice exposed to methyl isocyanate by inhalation. Environmental mutagenesis, 9(1), 29-36. https://doi.org/10.1002/em.2860090105
Kligerman, A D, et al. "Sister chromatid exchange analysis in lung and peripheral blood lymphocytes of mice exposed to methyl isocyanate by inhalation." Environmental mutagenesis vol. 9,1 (1987): 29-36. doi: https://doi.org/10.1002/em.2860090105
Kligerman AD, Campbell JA, Erexson GL, Allen JW, Shelby MD. Sister chromatid exchange analysis in lung and peripheral blood lymphocytes of mice exposed to methyl isocyanate by inhalation. Environ Mutagen. 1987;9(1):29-36. doi: 10.1002/em.2860090105. PMID: 3803323.
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Environ Mutagen. 1987;9(1):29-36. doi: 10.1002/em.2860090105.

Sister chromatid exchange analysis in lung and peripheral blood lymphocytes of mice exposed to methyl isocyanate by inhalation.

Environmental mutagenesis

A D Kligerman, J A Campbell, G L Erexson, J W Allen, M D Shelby

PMID: 3803323 DOI: 10.1002/em.2860090105

Abstract

Mice were exposed to 1, 3, or 6 ppm methyl isocyanate (MIC) for 6 hr/day for four consecutive days. Lung cells and peripheral blood lymphocytes (PBLs) were removed and cultured for analysis of sister chromatid exchange (SCE) and cell cycle kinetics. MIC caused a small but significant increase in SCE frequency of cultured lung cells from mice exposed to 1, 3, or 6 ppm MIC. MIC did not significantly increase SCE levels in PBLs of mice exposed to concentrations as high as 6 ppm. In cultured PBLs, MIC had a stimulatory effect on cell cycling rates as measured by the replicative index, and it caused a significant reduction in mononuclear leucocyte counts and the mitotic indices.

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