Display options
Cite
Krämer G, Theisohn M, von Unruh GE, et al. Carbamazepine-danazol drug interaction: its mechanism examined by a stable isotope technique. Ther Drug Monit. 1986;8(4):387-92
Krämer, G., Theisohn, M., von Unruh, G. E., & Eichelbaum, M. (1986). Carbamazepine-danazol drug interaction: its mechanism examined by a stable isotope technique. Therapeutic drug monitoring, 8(4), 387-92.
Krämer, G, et al. "Carbamazepine-danazol drug interaction: its mechanism examined by a stable isotope technique." Therapeutic drug monitoring vol. 8,4 (1986): 387-92.
Krämer G, Theisohn M, von Unruh GE, Eichelbaum M. Carbamazepine-danazol drug interaction: its mechanism examined by a stable isotope technique. Ther Drug Monit. 1986;8(4):387-92. PMID: 3824425.
Copy Download .nbib Format: NLM
Share it on

Ther Drug Monit. 1986;8(4):387-92.

Carbamazepine-danazol drug interaction: its mechanism examined by a stable isotope technique.

Therapeutic drug monitoring

G Krämer, M Theisohn, G E von Unruh, M Eichelbaum

PMID: 3824425

Abstract

Carbamazepine (CBZ) labeled with 15N was used to investigate the mechanism of its pharmacokinetic interaction with the antiestrogenic steroid danazol during treatment of a patient with epilepsy. Danazol led to a pronounced inhibition of CBZ metabolism. During danazol coadministration, CBZ elimination half-life increased from a pretreatment value of 11 to 24.3 h. Carbamazepine plasma clearance decreased from 57.7 to 23.2 ml/h/kg. Kinetic analysis of the plasma concentration-time curves and urinary excretion of [15N]trans-CBZ-diol revealed that danazol inhibited the epoxide-trans-diol pathway of carbamazepine metabolism. Observations in five other female patients confirm that the steady-state plasma concentrations of UCBZ increase between 50 and 100% during coadministration of danazol.

Substances

MeSH terms

Publication Types

LinkOut - more resources