Human leukemic models of myelomonocytic development: a review of the HL-60 and U937 cell lines.

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J Leukoc Biol. 1985 Apr;37(4):407-22. doi: 10.1002/jlb.37.4.407.

Human leukemic models of myelomonocytic development: a review of the HL-60 and U937 cell lines.

Journal of leukocyte biology

P Harris, P Ralph

PMID: 3855947 DOI: 10.1002/jlb.37.4.407

Abstract

The human leukemic myeloblast HL-60 and monoblast U937 cell lines have made important contributions to the disciplines of cancer, hematology, and immunology. As sources of leukemic cells, they have been used for the study of neoplasia and therapeutics. As sources of hemic cells, they have been used for biochemical and biological analysis of regulation and differentiation in myelopoiesis. When stimulated with immunomodulatory factors, the cell lines develop properties of host-defense effector cells. They are also a source of cytokines that affect other cell types.

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