Seven patients with multiple myeloma who developed a second neoplasm are presented. There were four patients with acute leukemia and three patients with non-hematologic neoplasms. The patients with acute leukemia were among the longest survivors (median duration approximately 72 months) and the response to anti-leukemic therapy in these patients was generally poor. Of the three patients with non=hematologic neoplasms, one patient was observed with simultaneous renal cell carcinoma and the other two patients developed adenocarcinoma of the colon and lung subsequently. In addition, two patients with mammary carcinoma who subsequently developed multiple myeloma were included. Literature was reviewed and the possibility that multiple myeloma itself might be a risk factor for the development of other malignancies was discussed.
Musto P, Anderson KC, Attal M, Richardson PG, Badros A, Hou J, Comenzo R, Du J, Durie BGM, San Miguel J, Einsele H, Chen WM, Garderet L, Pietrantuono G, Hillengass J, Kyle RA, Moreau P, Lahuerta JJ, Landgren O, Ludwig H, Larocca A, Mahindra A, Cavo M, Mazumder A, McCarthy PL, Nouel A, Rajkumar SV, Reiman A, Riva E, Sezer O, Terpos E, Turesson I, Usmani S, Weiss BM, Palumbo A.
Ann Oncol. 2018 Apr 01;29(4):1074. doi: 10.1093/annonc/mdx160.
PMID: 28541409
Ji SH, Park JO, Lee J, Oh MJ, Lim DH, Park BB, Park KW, Lee SH, Kim K, Kim WS, Jung CW, Park YS, Im YH, Kang WK, Lee MH, Park K.
Cancer Res Treat. 2004 Oct;36(5):338-40. doi: 10.4143/crt.2004.36.5.338. Epub 2004 Oct 31.
PMID: 20368825
