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Alvis JM, Reves JG, Govier AV, et al. Computer-assisted continuous infusions of fentanyl during cardiac anesthesia: comparison with a manual method. Anesthesiology. 1985;63(1):41-9doi: 10.1097/00000542-198507000-00006.
Alvis, J. M., Reves, J. G., Govier, A. V., Menkhaus, P. G., Henling, C. E., Spain, J. A., & Bradley, E. (1985). Computer-assisted continuous infusions of fentanyl during cardiac anesthesia: comparison with a manual method. Anesthesiology, 63(1), 41-9. https://doi.org/10.1097/00000542-198507000-00006
Alvis, J M, et al. "Computer-assisted continuous infusions of fentanyl during cardiac anesthesia: comparison with a manual method." Anesthesiology vol. 63,1 (1985): 41-9. doi: https://doi.org/10.1097/00000542-198507000-00006
Alvis JM, Reves JG, Govier AV, Menkhaus PG, Henling CE, Spain JA, Bradley E. Computer-assisted continuous infusions of fentanyl during cardiac anesthesia: comparison with a manual method. Anesthesiology. 1985 Jul;63(1):41-9. doi: 10.1097/00000542-198507000-00006. PMID: 3874568.
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Anesthesiology. 1985 Jul;63(1):41-9. doi: 10.1097/00000542-198507000-00006.

Computer-assisted continuous infusions of fentanyl during cardiac anesthesia: comparison with a manual method.

Anesthesiology

J M Alvis, J G Reves, A V Govier, P G Menkhaus, C E Henling, J A Spain, E Bradley

PMID: 3874568 DOI: 10.1097/00000542-198507000-00006
Free Article

Abstract

The design and implementation of a computer-assisted continuous infusion (CACI) system to rapidly attain and maintain a constant plasma fentanyl concentration (PFC), as well as a CACI system that allowed the anesthesiologist to change the plasma level of fentanyl during cardiac anesthesia, were developed. In 30 patients (three groups of 10 patients each) these two automated methods of fentanyl infusion were compared with a manual fentanyl administration method. There was excellent agreement in the measured/predicted PFC ratios with the CACI stable fentanyl level system (ratio = 0.99, n = 91) and in the CACI variable fentanyl level system (ratio = 1.08, n = 79). The stable fentanyl level group of patients received significantly more (P less than 0.05) fentanyl than did the other groups. The CACI variable fentanyl level group of patients had greater hemodynamic stability, required significantly (P less than 0.05) fewer adjuvant drug interventions and experienced significantly (P less than 0.05) fewer hypotensive and hypertensive episodes than the manual, bolus fentanyl (control) group. These data show that a computer-assisted automated infusion of fentanyl is safe and as good as manual methods. CACI has greater potential as a new method of intravenous anesthesia administration.

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