Am J Nephrol. 1985;5(4):236-42. doi: 10.1159/000166941.

Antiproteinuric effect of naproxen and indomethacin. A double-blind crossover study.

American journal of nephrology

R Vriesendorp, A J Donker, D de Zeeuw, P E de Jong, G K van der Hem

PMID: 3901756 DOI: 10.1159/000166941

Abstract

In a double-blind crossover study in 10 salt-depleted nephrotic patients the reduction of proteinuria was significantly larger during indomethacin 50 mg three times daily than during naproxen 250 or 500 mg three times daily (72 vs. 44%, p less than 0.05; 77 vs. 46%, p less than 0.05, respectively). Both drugs induced similar reversible intrarenal hemodynamic changes, but indomethacin had more pronounced effects than naproxen. A common pathway, such as the reduction of the glomerular filtration rate and a reduction of the glomerular transcapillary hydraulic pressure, is likely to explain the observed phenomena and is most probably mediated by inhibition of intrarenal prostaglandin synthesis. If treatment with a nonsteroidal anti-inflammatory drug is considered in patients with the idiopathic nephrotic syndrome, indomethacin appears up to now the most effective agent in reducing urinary protein loss.

Cited by

Substances

• Naproxen
• Renin
• Indomethacin

MeSH terms

• Adult
• Aged
• Clinical Trials as Topic
• Double-Blind Method
• Female
• Glomerular Filtration Rate / drug effects
• Humans
• Indomethacin / administration & dosage
• Indomethacin / therapeutic use
• Male
• Middle Aged
• Naproxen / administration & dosage
• Naproxen / therapeutic use
• Nephrotic Syndrome / complications
• Nephrotic Syndrome / drug therapy
• Nephrotic Syndrome / physiopathology
• Proteinuria / complications
• Proteinuria / drug therapy
• Proteinuria / physiopathology
• Renal Circulation / drug effects
• Renin / blood

Publication Types

• Journal Article
• Research Support, Non-U.S. Gov't

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