Display options
Cite
Nattrass M, Todd PG, Hinks L, et al. Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics. Diabetologia. 1977;13(2):145-52doi: 10.1007/BF00745143.
Nattrass, M., Todd, P. G., Hinks, L., Lloyd, B., & Alberti, K. G. (1977). Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics. Diabetologia, 13(2), 145-52. https://doi.org/10.1007/BF00745143
Nattrass, M, et al. "Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics." Diabetologia vol. 13,2 (1977): 145-52. doi: https://doi.org/10.1007/BF00745143
Nattrass M, Todd PG, Hinks L, Lloyd B, Alberti KG. Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics. Diabetologia. 1977 Apr;13(2):145-52. doi: 10.1007/BF00745143. PMID: 404205.
Copy Download .nbib Format: NLM
Share it on

Diabetologia. 1977 Apr;13(2):145-52. doi: 10.1007/BF00745143.

Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics.

Diabetologia

M Nattrass, P G Todd, L Hinks, B Lloyd, K G Alberti

PMID: 404205 DOI: 10.1007/BF00745143

Abstract

Twelve hour metabolic rhythms have been performed on six maturity-onset diabetic subjects during successive periods of therapy with phenformin, metformin, and glibenclamide. Moderate control of blood glucose concentration was achieved with phenformin and metformin, the lowest concentrations being found with glibenclamide. Mean blood lactate concentration was grossly elevated during phenformin therapy, moderately elevated with metformin and normal during glibenclamide treatment. Similar patterns were found for the lactate/pyruvate ratio, alanine, glycerol and ketone bodies. Serum triglyceride concentrations were significantly higher during phenformin treatment than with the other two regimes. Serum insulin concentration was higher on glibenclamide than with either biguanide. Most of these effects of the biguanides could be accounted for by an inhibitory effect on hepatic gluconeogenesis. It is concluded that the use of biguanides as hypoglycaemic agents in diabetes is associated with the production of multiple metabolic abnormalities.

Similar articles

Show all 9 similar articles

Cited by

Alves-Silva AB, Fenerich BA, Fonseca NP, Fernandes JC, Coelho-Silva JL, Pereira-Martins DA, Bianco TM, Scheucher PS, Rego EM, Chahud F, Machado-Neto JA, Figueiredo-Pontes LL, Traina F.
Invest New Drugs. 2022 Jan 11; doi: 10.1007/s10637-022-01212-y. Epub 2022 Jan 11.
PMID: 35015172

References

  1. J Clin Endocrinol Metab. 1952 May;12(9):1245-6 - PubMed
  2. Diabetologia. 1971 Oct;7(5):379-85 - PubMed
  3. J Med Lab Technol. 1970 Jul;27(3):359-82 - PubMed
  4. Nature. 1967 Jan 14;213(5072):203-4 - PubMed
  5. Isr J Med Sci. 1975 Jun;11(6):571-80 - PubMed
  6. Br Med J. 1972 Jan 22;1(5794):205-6 - PubMed
  7. Diabetes. 1960 May-Jun;9:186-93 - PubMed
  8. Diabetes. 1975 Sep;24(9):791-800 - PubMed
  9. Br Med J. 1973 Sep 29;3(5882):673-5 - PubMed
  10. Diabetes. 1968 Aug;17(8):492-8 - PubMed
  11. Ann N Y Acad Sci. 1968 Mar 26;148(3):937-44 - PubMed
  12. Ann N Y Acad Sci. 1968 Mar 26;148(3):884-91 - PubMed
  13. Br Med J. 1974 Dec 21;4(5946):699-700 - PubMed
  14. Diabetologia. 1968 Aug;4(4):221-8 - PubMed
  15. Biochem J. 1974 Oct;144(1):49-57 - PubMed
  16. Anal Biochem. 1969 Oct 1;31(1):426-36 - PubMed
  17. Diabetologia. 1967 Oct;3(5):413-21 - PubMed
  18. J Biol Chem. 1973 Aug 10;248(15):5272-7 - PubMed
  19. Diabetes. 1965 Dec;14(12):771-9 - PubMed
  20. Br Med J. 1959 Nov 14;2(5158):1005-6 - PubMed
  21. Biochem J. 1962 Jan;82:90-6 - PubMed
  22. Clin Chem. 1973 Dec;19(12):1391-3 - PubMed
  23. Metabolism. 1972 Mar;21(3):179-86 - PubMed
  24. Diabetes. 1960 May-Jun;9:194-201 - PubMed
  25. Diabetes. 1962 Jul-Aug;11:281-6 - PubMed
  26. Rev Esp Fisiol. 1971 Sep;27(3):253-6 - PubMed
  27. Biochem Pharmacol. 1976 Sep 15;25(18):2015-24 - PubMed
  28. Ann N Y Acad Sci. 1968 Mar 26;148(3):612-22 - PubMed
  29. Diabete. 1964 Oct;12:239-45 - PubMed
  30. Acta Med Scand. 1975 Jul-Aug;198(1-2):127-33 - PubMed
  31. Diabetologia. 1973 Feb;9(1):6-12 - PubMed
  32. Diabetes. 1966 Mar;15(3):173-8 - PubMed

Substances

MeSH terms

Publication Types