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Morley CG, Bezkorovainy A. Cellular iron uptake from transferrin: is endocytosis the only mechanism?. Int J Biochem. 1985;17(5):553-64doi: 10.1016/0020-711x(85)90286-1.
Morley, C. G., & Bezkorovainy, A. (1985). Cellular iron uptake from transferrin: is endocytosis the only mechanism?. The International journal of biochemistry, 17(5), 553-64. https://doi.org/10.1016/0020-711x(85)90286-1
Morley, C G, and Bezkorovainy, A. "Cellular iron uptake from transferrin: is endocytosis the only mechanism?." The International journal of biochemistry vol. 17,5 (1985): 553-64. doi: https://doi.org/10.1016/0020-711x(85)90286-1
Morley CG, Bezkorovainy A. Cellular iron uptake from transferrin: is endocytosis the only mechanism?. Int J Biochem. 1985;17(5):553-64. doi: 10.1016/0020-711x(85)90286-1. PMID: 3896889.
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Int J Biochem. 1985;17(5):553-64. doi: 10.1016/0020-711x(85)90286-1.

Cellular iron uptake from transferrin: is endocytosis the only mechanism?.

The International journal of biochemistry

C G Morley, A Bezkorovainy

PMID: 3896889 DOI: 10.1016/0020-711x(85)90286-1

Abstract

Receptor mediated endocytosis has been proposed as the method of cellular iron uptake from transferrin (TF). However, the experimental evidence for endocytosis in every situation is found wanting. This is particularly true for the hepatocyte where an alternative mechanism of iron release at the cell surface can account for all iron uptake. It may be, that under appropriate physiological conditions (e.g. degree of iron saturation of TF) cells may take up iron by either an endocytotic or nonendocytotic mechanism.

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