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Imbach P, Odavic R, Bleher EA, et al. Autologe Knochenmark-Reimplantation bei Kindern mit fortgeschrittenem Tumor. [Autologous bone marrow reimplantation in children with advanced tumor. First experiences of feasibility]. Schweiz Med Wochenschr. 1979;109(8):283-7
Imbach, P., Odavic, R., Bleher, E. A., Bucher, U., Deubelbeiss, K. A., & Wagner, H. P. (1979). Autologe Knochenmark-Reimplantation bei Kindern mit fortgeschrittenem Tumor. [Autologous bone marrow reimplantation in children with advanced tumor. First experiences of feasibility]. Schweizerische medizinische Wochenschrift, 109(8), 283-7.
Imbach, P, et al. "Autologe Knochenmark-Reimplantation bei Kindern mit fortgeschrittenem Tumor." [Autologous bone marrow reimplantation in children with advanced tumor. First experiences of feasibility]. Schweizerische medizinische Wochenschrift vol. 109,8 (1979): 283-7.
Imbach P, Odavic R, Bleher EA, Bucher U, Deubelbeiss KA, Wagner HP. Autologe Knochenmark-Reimplantation bei Kindern mit fortgeschrittenem Tumor. [Autologous bone marrow reimplantation in children with advanced tumor. First experiences of feasibility]. Schweiz Med Wochenschr. 1979 Feb 24;109(8):283-7. German. PMID: 373111.
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Schweiz Med Wochenschr. 1979 Feb 24;109(8):283-7.

[Autologous bone marrow reimplantation in children with advanced tumor. First experiences of feasibility].

Schweizerische medizinische Wochenschrift

[Article in German]
P Imbach, R Odavic, E A Bleher, U Bucher, K A Deubelbeiss, H P Wagner

PMID: 373111

Abstract

In three children with metastatic tumor uncontrollable by conventional chemo- and radiotherapy, bone marrow was obtained under general anesthesia and cryopreserved according to a carefully developed protocol. The autologous bone marrow cells were reinfused after intensive cytostatic therapy and total body irradiation (2 patients). After an aplastic phase of 7--14 days the peripheral blood leukocyte and thrombocyte count began to recover. The toxicity of the intensive treatment preceding the autologous bone marrow transfusion, and the autologous bone marrow cells themselves were well tolerated. The aplastic phase was easily controlled by the use of granulocytes, thrombocytes and erythrocytes. Except for fever and mucosal ulcerations observed during the phase of extreme leukopenia, the general condition of the patients during partial isolation lasting 26--34 days was astonishingly good. One child died 13 weeks after returning home due to a local relapse. The other two patients survived for 6 + and 11 + weeks and are in complete and partial remission respectively. A further evaluation of the clinical significance of autologous bone marrow reimplantations appears to be feasible in pediatric oncology.

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