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Allars J, York DA. The effects of 2-deoxy-D-glucose on brown adipose tissue of lean and obese Zucker rats. Int J Obes. 1986;10(2):147-58
Allars, J., & York, D. A. (1986). The effects of 2-deoxy-D-glucose on brown adipose tissue of lean and obese Zucker rats. International journal of obesity, 10(2), 147-58.
Allars, J, and York, D A. "The effects of 2-deoxy-D-glucose on brown adipose tissue of lean and obese Zucker rats." International journal of obesity vol. 10,2 (1986): 147-58.
Allars J, York DA. The effects of 2-deoxy-D-glucose on brown adipose tissue of lean and obese Zucker rats. Int J Obes. 1986;10(2):147-58. PMID: 3721700.
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Int J Obes. 1986;10(2):147-58.

The effects of 2-deoxy-D-glucose on brown adipose tissue of lean and obese Zucker rats.

International journal of obesity

J Allars, D A York

PMID: 3721700

Abstract

The response of brown adipose tissue (BAT) thermogenesis, as measured by mitochondrial GDP binding, of lean and obese Zucker fa/fa rats to 2-deoxy-D-glucose (2-DOG) has been investigated. 2-DOG reduced BAT mitochondrial GDP binding of lean rats but had no effect in obese rats. Adrenalectomy increased BAT GDP binding in obese rats and restored the 2-DOG inhibitory effect. Corticosterone inhibited GDP binding in lean rats and abolished the 2-DOG inhibitory effect. 2-DOG induced hyperphagia and hyperglycaemia in lean rats, but these effects were either absent or attenuated in the obese. The possibility that a glucocorticoid inhibition of glucose metabolism impairs sympathetic activity in the obese rats is discussed.

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