Display options
Share it on
Full text links
HighWire Free PMC Article

J Neurol Neurosurg Psychiatry. 1987 Oct;50(10):1337-41. doi: 10.1136/jnnp.50.10.1337.

Peripheral nerve function in patients with painful diabetic neuropathy treated with continuous subcutaneous insulin infusion.

Journal of neurology, neurosurgery, and psychiatry

F W Bertelsmann, J J Heimans, J C Van Rooy, H F Dankmeijer, S L Visser, E A Van der Veen

Affiliations

  1. Department of Neurology, Free University Hospital, Amsterdam, The Netherlands.

PMID: 3681313 PMCID: PMC1032461 DOI: 10.1136/jnnp.50.10.1337
Free PMC Article

Abstract

In order to study the effects of improved metabolic control on painful diabetic polyneuropathy, 15 patients were treated with continuous subcutaneous insulin infusion over a 12 month period. Polyneuropathy was assessed by pain score, neurological examinations, nerve conduction studies and determination of sensory thresholds and cardiovascular reflexes. Improved metabolic control was confirmed by significantly improved levels of glycosylated haemoglobin (11.7 +/- 0.3% at entry to the study, to 8.7 +/- 0.3% after 12 months; mean +/- SEM). Symptomatic relief was confirmed by significantly improved pain scores. Thresholds for thermal cutaneous sensation improved significantly from 6.0 +/- 0.8 degrees C at entry to the study to 2.7 +/- 0.7 degrees C after 12 months (mean +/- SEM). These findings suggest a selective improvement of peripheral small nerve fibre function after continuous subcutaneous insulin infusion. The importance of quantitating thermal cutaneous sensation in longitudinal studies of patients with diabetic neuropathy was confirmed.

Cited by

References

  1. Pain. 1976 Jun;2(2):175-84 - PubMed
  2. Diabetes Res. 1986 Nov;3(9):463-6 - PubMed
  3. Diabetes Care. 1980 Mar-Apr;3(2):301-8 - PubMed
  4. Q J Med. 1980 Winter;49(193):95-108 - PubMed
  5. Diabetes. 1980 Aug;29(8):668-71 - PubMed
  6. South Med J. 1982 Feb;75(2):185-9 - PubMed
  7. Diabetologia. 1982 Mar;22(3):163-6 - PubMed
  8. Diabetes Care. 1982 Jul-Aug;5(4):386-90 - PubMed
  9. Diabetes. 1982 Mar;31(3):255-64 - PubMed
  10. Lancet. 1983 Jan 29;1(8318):204-8 - PubMed
  11. Mayo Clin Proc. 1983 May;58(5):283-9 - PubMed
  12. Nervenarzt. 1984 Feb;55(2):103-7 - PubMed
  13. Ann Neurol. 1984 Jan;15(1):2-12 - PubMed
  14. Ann Neurol. 1984 Aug;16(2):178-83 - PubMed
  15. Diabetes Care. 1985 May-Jun;8(3):290-9 - PubMed
  16. J Neurol Neurosurg Psychiatry. 1985 Jul;48(7):686-90 - PubMed
  17. Horm Metab Res. 1985 Aug;17(8):410-3 - PubMed
  18. Diabetologia. 1985 Oct;28(10):722-7 - PubMed
  19. J Neurol Sci. 1986 Jun;74(1):1-9 - PubMed
  20. J Neurol Sci. 1986 Jul;74(2-3):191-7 - PubMed
  21. Acta Neurol Scand. 1986 Aug;74(2):121-7 - PubMed
  22. Br Med J (Clin Res Ed). 1986 Nov 8;293(6556):1195-9 - PubMed
  23. Diabetes Care. 1980 Mar-Apr;3(2):290-300 - PubMed

MeSH terms

Publication Types

LinkOut - more resources