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Mochida K, Shiraki C, Yamasaki M, et al. Aminothiazolylglycyl derivatives of carbacephems. I. Synthesis and antibacterial activity of novel carbacephems with substituted aminothiazolyl groups. J Antibiot (Tokyo). 1987;40(1):14-21doi: 10.7164/antibiotics.40.14.
Mochida, K., Shiraki, C., Yamasaki, M., Hirata, T., Sato, K., & Okachi, R. (1987). Aminothiazolylglycyl derivatives of carbacephems. I. Synthesis and antibacterial activity of novel carbacephems with substituted aminothiazolyl groups. The Journal of antibiotics, 40(1), 14-21. https://doi.org/10.7164/antibiotics.40.14
Mochida, K, et al. "Aminothiazolylglycyl derivatives of carbacephems. I. Synthesis and antibacterial activity of novel carbacephems with substituted aminothiazolyl groups." The Journal of antibiotics vol. 40,1 (1987): 14-21. doi: https://doi.org/10.7164/antibiotics.40.14
Mochida K, Shiraki C, Yamasaki M, Hirata T, Sato K, Okachi R. Aminothiazolylglycyl derivatives of carbacephems. I. Synthesis and antibacterial activity of novel carbacephems with substituted aminothiazolyl groups. J Antibiot (Tokyo). 1987 Jan;40(1):14-21. doi: 10.7164/antibiotics.40.14. PMID: 3558115.
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J Antibiot (Tokyo). 1987 Jan;40(1):14-21. doi: 10.7164/antibiotics.40.14.

Aminothiazolylglycyl derivatives of carbacephems. I. Synthesis and antibacterial activity of novel carbacephems with substituted aminothiazolyl groups.

The Journal of antibiotics

K Mochida, C Shiraki, M Yamasaki, T Hirata, K Sato, R Okachi

PMID: 3558115 DOI: 10.7164/antibiotics.40.14

Abstract

A series of new carbacephem compounds which have substituted aminothiazolylglycyl side chain have been prepared starting from corresponding carbacephems with aminothiazolylmethoxyimino group. Among them, the compound having 3,4-dihydroxybenzoyl group showed very sharp activity against Pseudomonas aeruginosa. Moreover, the optical resolution of alpha carbon of aminothiazolylglycyl moiety was carried out through preparation of optically active side chain and the (S)-isomer (KT-4380) was found to be the most active against Pseudomonas sp. as well as other Gram-negative strains.

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