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Khouri MR, Saul SH, Dlugosz AA, et al. Hepatocanalicular injury associated with vitamin A derivative etretinate. An idiosyncratic hypersensitivity reaction. Dig Dis Sci. 1987;32(10):1207-11doi: 10.1007/BF01300208.
Khouri, M. R., Saul, S. H., Dlugosz, A. A., & Soloway, R. D. (1987). Hepatocanalicular injury associated with vitamin A derivative etretinate. An idiosyncratic hypersensitivity reaction. Digestive diseases and sciences, 32(10), 1207-11. https://doi.org/10.1007/BF01300208
Khouri, M R, et al. "Hepatocanalicular injury associated with vitamin A derivative etretinate. An idiosyncratic hypersensitivity reaction." Digestive diseases and sciences vol. 32,10 (1987): 1207-11. doi: https://doi.org/10.1007/BF01300208
Khouri MR, Saul SH, Dlugosz AA, Soloway RD. Hepatocanalicular injury associated with vitamin A derivative etretinate. An idiosyncratic hypersensitivity reaction. Dig Dis Sci. 1987 Oct;32(10):1207-11. doi: 10.1007/BF01300208. PMID: 3652901.
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Dig Dis Sci. 1987 Oct;32(10):1207-11. doi: 10.1007/BF01300208.

Hepatocanalicular injury associated with vitamin A derivative etretinate. An idiosyncratic hypersensitivity reaction.

Digestive diseases and sciences

M R Khouri, S H Saul, A A Dlugosz, R D Soloway

Affiliations

  1. Department of Medicine, Hospital of the University of Pennsylvania, School of Medicine, Philadelphia 19104.

PMID: 3652901 DOI: 10.1007/BF01300208

Abstract

A patient with pustular psoriasis developed jaundice, peripheral blood eosinophilia, and biochemical evidence of hepatocanalicular dysfunction four weeks after the initiation of etretinate therapy. A liver biopsy specimen showed bile duct damage, a periportal inflammatory infiltrate composed of neutrophils, eosinophils and lymphocytes, canalicular cholestasis, and focal hepatocyte necrosis. Clinical exclusion of other possible etiologic factors coupled with near resolution of the biochemical abnormalities within six weeks after complete discontinuation of the drug indicates that etretinate may induce an idiosyncratic hypersensitivity reaction. This is the first report to document etretinate associated bile duct injury.

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