Chemioterapia. 1986 Dec;5(6):411-3.
Chemioterapia : international journal of the Mediterranean Society of Chemotherapy
N Ragni, G Foglia, M Ruvolo, P Repetto, G Cordone, M Madaro, S Chiara, M Bruzzone
Carboplatin (JM8), a new cisdiamminodichloroplatin (CDDP) analogue, has exhibited the same antitumor as CDDP. In our pilot study, aiming at optimizing the dosage of this drug in a combination regimen with other chemotherapics, we planned to evaluate the existence of drug related damage on cochleo-vestibular structures. The study was performed on 9 patients suffering from advanced ovarian carcinoma. The results obtained in our study showed that patients undergoing carboplatin chemotherapy do not require an audiometric check-up. In order to assess definitely the existence of vestibular toxicity of this drug, larger studies planned to test JM8 in a high-dosage regimen are desirable.