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Mölleken K. Morphologie, Häufigkeit und klinische Bedeutung von Leberparenchymveränderungen nach Anwendung hormonaler Kontrazeptiva. [Morphology, incidence and clinical significance of changes in the liver parenchyma following use of hormonal contraceptives]. Z Gesamte Inn Med. 1986;41(22):618-23
Mölleken, K. (1986). Morphologie, Häufigkeit und klinische Bedeutung von Leberparenchymveränderungen nach Anwendung hormonaler Kontrazeptiva. [Morphology, incidence and clinical significance of changes in the liver parenchyma following use of hormonal contraceptives]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 41(22), 618-23.
Mölleken, K. "Morphologie, Häufigkeit und klinische Bedeutung von Leberparenchymveränderungen nach Anwendung hormonaler Kontrazeptiva." [Morphology, incidence and clinical significance of changes in the liver parenchyma following use of hormonal contraceptives]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete vol. 41,22 (1986): 618-23.
Mölleken K. Morphologie, Häufigkeit und klinische Bedeutung von Leberparenchymveränderungen nach Anwendung hormonaler Kontrazeptiva. [Morphology, incidence and clinical significance of changes in the liver parenchyma following use of hormonal contraceptives]. Z Gesamte Inn Med. 1986 Nov 15;41(22):618-23. German. PMID: 3564586.
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Z Gesamte Inn Med. 1986 Nov 15;41(22):618-23.

[Morphology, incidence and clinical significance of changes in the liver parenchyma following use of hormonal contraceptives].

Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete

[Article in German]
K Mölleken

PMID: 3564586

Abstract

Among 438 liver punctates of women who had used oral contraceptives and who showed a clinical symptomatology or pathological laboratory values in 332 cases (75.8%) morphologically recognizable changes were formed which spoke for a causal connection with the application of hormonal contraceptives. Pathological-anatomically 5 various types of damage may be differed, in which cases frequently a combination of findings is present: uncharacteristic lesions with epithelial and mesenchymal changes, disturbances of the microcirculation in form of sinusoid ectasias up to the development of a peliosis hepatis and intrahepatic venous thrombi, intrahepatic cholestasis without any essential inflammatory reaction, hepatitic changes, liver tumours and tumour-like lesions. The clinical importance and valency of the individual changes is different, whereby exclusive uncharacteristic findings mostly have no pathological value, whereas a cholestasis and hepatic changes as well as tumours demand an end of the medication. Most frequently sinusoid ectasias occur; they represent the most important morphologic indicator of a lesion of the liver parenchyma after application of hormonal contraceptives.

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