Gan To Kagaku Ryoho. 1987 Apr;14(4):1018-24.
Gan to kagaku ryoho. Cancer & chemotherapy
[Article in Japanese] S Matsumoto, N Kawaguchi, K Amino, J Manabe, K Furuya, Y Isobe
Cisplatin was administered by intravenous injection, intra-arterial injection, and balloon-occluded arterial infusion. The total Pt, ultrafiltrated Pt, and free Pt levels were measured. Intra-arterial injection, in which ultra-filtrated Pt level on the normal side is the same as in intravenous injection, acts to increase the ultrafiltrated Pt level on the affected side. Thus, intra-arterial injection is as effective as preoperative chemotherapy. In two-route chemotherapy, free Pt level on the affected side is extremely high, so for only local control of tumors, two-route chemotherapy is very effective.