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Randall J, Obeid ML, Blackledge GR. Haemorrhage and perforation of gastrointestinal neoplasms during chemotherapy. Ann R Coll Surg Engl. 1986;68(5):286-9
Randall, J., Obeid, M. L., & Blackledge, G. R. (1986). Haemorrhage and perforation of gastrointestinal neoplasms during chemotherapy. Annals of the Royal College of Surgeons of England, 68(5), 286-9.
Randall, J, et al. "Haemorrhage and perforation of gastrointestinal neoplasms during chemotherapy." Annals of the Royal College of Surgeons of England vol. 68,5 (1986): 286-9.
Randall J, Obeid ML, Blackledge GR. Haemorrhage and perforation of gastrointestinal neoplasms during chemotherapy. Ann R Coll Surg Engl. 1986 Sep;68(5):286-9. PMID: 3491572; PMCID: PMC2498310.
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Ann R Coll Surg Engl. 1986 Sep;68(5):286-9.

Haemorrhage and perforation of gastrointestinal neoplasms during chemotherapy.

Annals of the Royal College of Surgeons of England

J Randall, M L Obeid, G R Blackledge

PMID: 3491572 PMCID: PMC2498310
Free PMC Article

Abstract

Gastrointestinal haemorrhage and perforation are known complications of cytotoxic therapy for chemosensitive tumours involving the wall of the gut, in particular non-Hodgkin's lymphoma. These complications can be avoided by aggressive surgery before chemotherapy is started. When they do occur, early operative intervention is essential to reduce morbidity and mortality. We report 4 cases in whom delay in diagnosis and surgery led to 3 deaths and suggest a policy for the management of such cases in the future.

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