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Taylor & Francis

Acta Otolaryngol. 1986 Sep-Oct;102(3):222-7. doi: 10.3109/00016488609108670.

Calcium transport in the endolymphatic space of cochlea and vestibular organ.

Acta oto-laryngologica

O Ninoyu, A M Meyer zum Gottesberge

PMID: 3490734 DOI: 10.3109/00016488609108670

Abstract

Ca++ concentrations and d.c. potential within the endolymphatic space of the cochlear duct and the semicircular canal following acute anoxia or ethacrynic acid intoxication (100 mg/kg i.v.) were measured by means of double-barrelled microelectrodes. Ionic calcium content and d.c. potential were found to change in a roughly biphasic fashion after either intervention. The maximal increase in Ca++ concentration coincided with the decline in the d.c. potential, which after a rapid decline finally reached and maintained negative voltages. This phenomenon was more pronounced in the cochlear part than in the semicircular canal. A model of calcium homeostasis is proposed in an attempt to reconcile the data presented with earlier evidence.

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