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Greenwell AA, Gopal K, Ussher JR. Myocardial Energy Metabolism in Non-ischemic Cardiomyopathy. Front Physiol. 2020;11:570421doi: 10.3389/fphys.2020.570421.
Greenwell, A. A., Gopal, K., & Ussher, J. R. (2020). Myocardial Energy Metabolism in Non-ischemic Cardiomyopathy. Frontiers in physiology, 11570421. https://doi.org/10.3389/fphys.2020.570421
Greenwell, Amanda A, et al. "Myocardial Energy Metabolism in Non-ischemic Cardiomyopathy." Frontiers in physiology vol. 11 (2020): 570421. doi: https://doi.org/10.3389/fphys.2020.570421
Greenwell AA, Gopal K, Ussher JR. Myocardial Energy Metabolism in Non-ischemic Cardiomyopathy. Front Physiol. 2020 Sep 16;11:570421. doi: 10.3389/fphys.2020.570421. eCollection 2020. PMID: 33041869; PMCID: PMC7526697.
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Front Physiol. 2020 Sep 16;11:570421. doi: 10.3389/fphys.2020.570421. eCollection 2020.

Myocardial Energy Metabolism in Non-ischemic Cardiomyopathy.

Frontiers in physiology

Amanda A Greenwell, Keshav Gopal, John R Ussher

Affiliations

  1. Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
  2. Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.
  3. Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.

PMID: 33041869 PMCID: PMC7526697 DOI: 10.3389/fphys.2020.570421

Abstract

As the most metabolically demanding organ in the body, the heart must generate massive amounts of energy adenosine triphosphate (ATP) from the oxidation of fatty acids, carbohydrates and other fuels (e.g., amino acids, ketone bodies), in order to sustain constant contractile function. While the healthy mature heart acts omnivorously and is highly flexible in its ability to utilize the numerous fuel sources delivered to it through its coronary circulation, the heart's ability to produce ATP from these fuel sources becomes perturbed in numerous cardiovascular disorders. This includes ischemic heart disease and myocardial infarction, as well as in various cardiomyopathies that often precede the development of overt heart failure. We herein will provide an overview of myocardial energy metabolism in the healthy heart, while describing the numerous perturbations that take place in various non-ischemic cardiomyopathies such as hypertrophic cardiomyopathy, diabetic cardiomyopathy, arrhythmogenic cardiomyopathy, and the cardiomyopathy associated with the rare genetic disease, Barth Syndrome. Based on preclinical evidence where optimizing myocardial energy metabolism has been shown to attenuate cardiac dysfunction, we will discuss the feasibility of myocardial energetics optimization as an approach to treat the cardiac pathology associated with these various non-ischemic cardiomyopathies.

Copyright © 2020 Greenwell, Gopal and Ussher.

Keywords: cardiac function; cardiomyopathy; energy metabolism; fatty acid oxidation; glucose oxidation

References

  1. J Clin Invest. 1990 May;85(5):1648-56 - PubMed
  2. J Clin Invest. 2002 Jan;109(1):121-30 - PubMed
  3. Am J Med Genet C Semin Med Genet. 2013 Aug;163C(3):198-205 - PubMed
  4. Ann Med. 2007;39(8):594-607 - PubMed
  5. PLoS One. 2015 Jun 01;10(6):e0128561 - PubMed
  6. Circulation. 2004 Mar 30;109(12):1550-7 - PubMed
  7. J Biol Chem. 2019 Jul 26;294(30):11568-11578 - PubMed
  8. Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H2112-9 - PubMed
  9. J Am Coll Cardiol. 2009 Oct 13;54(16):1524-32 - PubMed
  10. Front Physiol. 2013 Apr 17;4:74 - PubMed
  11. Cardiovasc Ther. 2012 Dec;30(6):333-41 - PubMed
  12. Biochim Biophys Acta Mol Basis Dis. 2019 Apr 1;1865(4):810-821 - PubMed
  13. Cardiovasc Res. 2006 Feb 1;69(2):329-40 - PubMed
  14. Cardiovasc Res. 2011 Jan 1;89(1):148-56 - PubMed
  15. Circulation. 2016 Feb 23;133(8):706-16 - PubMed
  16. J Biol Chem. 2018 May 25;293(21):8182-8195 - PubMed
  17. Cardiovasc Res. 2016 May 15;110(2):249-57 - PubMed
  18. Nat Commun. 2018 Jul 26;9(1):2935 - PubMed
  19. Cell Metab. 2019 May 7;29(5):1119-1134.e12 - PubMed
  20. Circ Res. 2018 Mar 16;122(6):836-845 - PubMed
  21. Circ Heart Fail. 2012 Jul 1;5(4):493-503 - PubMed
  22. J Biol Chem. 2011 Jan 14;286(2):899-908 - PubMed
  23. Biochem J. 1978 Jun 15;172(3):377-87 - PubMed
  24. Circ Heart Fail. 2013 Sep 1;6(5):1039-48 - PubMed
  25. Circ Res. 2018 Jun 22;123(1):107-128 - PubMed
  26. N Engl J Med. 1994 Mar 31;330(13):913-9 - PubMed
  27. Am J Physiol Heart Circ Physiol. 2006 May;290(5):H1763-9 - PubMed
  28. Cardiovasc Res. 2011 Oct 1;92(1):10-8 - PubMed
  29. Circ Res. 2017 Sep 15;121(7):749-770 - PubMed
  30. J Clin Invest. 2010 Oct;120(10):3443-54 - PubMed
  31. Circ Res. 2017 Sep 15;121(7):784-802 - PubMed
  32. Circ Res. 2009 Mar 27;104(6):805-12 - PubMed
  33. N Engl J Med. 2001 Jun 14;344(24):1823-31 - PubMed
  34. Diabetes Care. 2016 Jul;39(7):1108-14 - PubMed
  35. Eur J Heart Fail. 2011 Dec;13(12):1283-9 - PubMed
  36. J Clin Invest. 1985 Nov;76(5):1819-27 - PubMed
  37. Lancet. 1963 Apr 13;1(7285):785-9 - PubMed
  38. Cell. 2018 Aug 9;174(4):780-784 - PubMed
  39. Am J Physiol. 1983 Jun;244(6):H839-43 - PubMed
  40. Circ Res. 2008 Aug 1;103(3):252-60 - PubMed
  41. N Engl J Med. 2007 Mar 15;356(11):1140-51 - PubMed
  42. Can J Cardiol. 2014 Aug;30(8):940-4 - PubMed
  43. Nat Med. 2004 Nov;10(11):1245-50 - PubMed
  44. Physiol Rev. 2009 Jul;89(3):1025-78 - PubMed
  45. Circ Res. 2016 Nov 11;119(11):1173-1176 - PubMed
  46. Circ Cardiovasc Imaging. 2017 May;10(5): - PubMed
  47. Circ Res. 2020 May 22;126(11):1501-1525 - PubMed
  48. J Lipid Res. 2007 Jul;48(7):1559-70 - PubMed
  49. J Nucl Cardiol. 2019 Nov 8;: - PubMed
  50. Circ Cardiovasc Genet. 2009 Oct;2(5):457-66 - PubMed
  51. Hypertension. 2004 Nov;44(5):662-7 - PubMed
  52. Cell Metab. 2020 May 5;31(5):909-919.e8 - PubMed
  53. Circulation. 2005 Aug 2;112(5):636-42 - PubMed
  54. Circ Res. 2010 Jul 23;107(2):233-41 - PubMed
  55. Cardiovasc Res. 2014 Jul 15;103(2):248-57 - PubMed
  56. Circulation. 1996 Dec 1;94(11):2837-42 - PubMed
  57. Peptides. 2018 Feb;100:94-100 - PubMed
  58. Circulation. 2001 Dec 11;104(24):2923-31 - PubMed
  59. Cardiovasc Res. 2017 Feb 02;113(4):399-410 - PubMed
  60. J Clin Invest. 2005 Mar;115(3):547-55 - PubMed
  61. Pediatrics. 2006 Aug;118(2):e337-46 - PubMed
  62. Biochim Biophys Acta. 1964 May 11;86:399-402 - PubMed
  63. Lancet. 2014 May 31;383(9932):1933-43 - PubMed
  64. J Mol Cell Cardiol. 2019 Jan;126:70-76 - PubMed
  65. J Lipid Res. 2013 May;54(5):1312-25 - PubMed
  66. Diabetes. 2009 Aug;58(8):1766-75 - PubMed
  67. Am J Cardiol. 1972 Nov 8;30(6):595-602 - PubMed
  68. Cardiovasc Res. 2009 May 1;82(2):351-60 - PubMed
  69. PLoS One. 2020 Apr 21;15(4):e0224713 - PubMed
  70. Cell Metab. 2016 Aug 9;24(2):200-2 - PubMed
  71. Biochim Biophys Acta Mol Basis Dis. 2020 May 1;1866(5):165712 - PubMed
  72. Biochim Biophys Acta. 2009 Nov;1787(11):1309-16 - PubMed
  73. Circ Res. 2017 Sep 15;121(7):855-873 - PubMed
  74. Cardiovasc Res. 2011 May 1;90(2):210-9 - PubMed
  75. Circ Res. 2012 Aug 31;111(6):728-38 - PubMed
  76. Diabetes. 2020 Jun;69(6):1292-1305 - PubMed
  77. Diabetes. 2015 Aug;64(8):2735-43 - PubMed
  78. Am J Physiol Heart Circ Physiol. 2010 Jul;299(1):H210-6 - PubMed
  79. Biochem Biophys Res Commun. 2012 Oct 26;427(3):441-3 - PubMed
  80. Am J Physiol Heart Circ Physiol. 2000 Apr;278(4):H1196-204 - PubMed
  81. J Lipid Res. 1999 Jun;40(6):1007-16 - PubMed
  82. Am J Physiol. 1994 Aug;267(2 Pt 2):H742-50 - PubMed
  83. Physiol Rev. 2005 Jul;85(3):1093-129 - PubMed
  84. Cardiovasc Res. 2015 Apr 1;105(4):397-408 - PubMed
  85. J Endocrinol. 2009 May;201(2):199-209 - PubMed
  86. J Mol Cell Cardiol. 2008 Jan;44(1):201-9 - PubMed
  87. Cell. 1990 Sep 7;62(5):999-1006 - PubMed
  88. Circ Res. 2007 Aug 17;101(4):335-47 - PubMed
  89. J Am Coll Cardiol. 2006 Feb 7;47(3):598-604 - PubMed
  90. Physiol Rev. 2010 Jan;90(1):207-58 - PubMed
  91. Circulation. 2001 Oct 2;104(14):1664-9 - PubMed
  92. Expert Rev Cardiovasc Ther. 2014 Mar;12(3):345-58 - PubMed
  93. Cardiovasc Res. 2019 Sep 1;115(11):1606-1616 - PubMed
  94. Cardiovasc Res. 1997 Apr;34(1):3-24 - PubMed
  95. Circ Res. 2017 Sep 15;121(7):722-730 - PubMed
  96. Endocrinology. 2013 Aug;154(8):2650-62 - PubMed
  97. Biochim Biophys Acta. 2011 Jul;1813(7):1333-50 - PubMed
  98. J Am Coll Cardiol. 2015 Mar 31;65(12):1249-1254 - PubMed
  99. Diabetes. 2013 Oct;62(10):3404-17 - PubMed
  100. J Am Soc Nephrol. 2013 Jul;24(8):1250-61 - PubMed
  101. Biochem Soc Trans. 2006 Apr;34(Pt 2):217-22 - PubMed
  102. Circulation. 2003 Apr 1;107(12):1664-70 - PubMed
  103. Circulation. 2020 Sep 8;142(10):983-997 - PubMed
  104. J Am Coll Cardiol. 2016 Dec 27;68(25):2850-2870 - PubMed
  105. J Biol Chem. 2016 Nov 4;291(45):23490-23505 - PubMed
  106. Cardiovasc Res. 2020 May 13;: - PubMed
  107. Diabetologia. 2007 Sep;50(9):1938-1948 - PubMed
  108. Biochim Biophys Acta. 2016 Oct;1861(10):1513-24 - PubMed
  109. J Am Coll Cardiol. 2002 Feb 20;39(4):718-25 - PubMed
  110. Sci Rep. 2019 Apr 2;9(1):5532 - PubMed
  111. Cell Metab. 2017 Feb 7;25(2):262-284 - PubMed
  112. J Clin Invest. 2000 Jun;105(12):1723-30 - PubMed
  113. J Am Heart Assoc. 2013 May 17;2(3):e004796 - PubMed
  114. Circ Arrhythm Electrophysiol. 2019 Nov;12(11):e007573 - PubMed
  115. Am J Physiol Heart Circ Physiol. 2017 Sep 1;313(3):H479-H490 - PubMed
  116. Circulation. 2007 Apr 17;115(15):2033-41 - PubMed
  117. Can J Physiol Pharmacol. 2005 Jan;83(1):24-8 - PubMed
  118. J Clin Invest. 2012 Mar;122(3):1109-18 - PubMed
  119. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1226-31 - PubMed
  120. Science. 1964 Jan 24;143(3604):371-3 - PubMed
  121. J Mol Cell Cardiol. 2018 Aug;121:94-102 - PubMed
  122. Front Pharmacol. 2018 Apr 11;9:318 - PubMed
  123. J Clin Invest. 2007 Dec;117(12):3930-9 - PubMed
  124. Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2096-108 - PubMed
  125. Diabetes. 2004 Sep;53(9):2366-74 - PubMed
  126. Diabetes. 2002 Aug;51(8):2587-95 - PubMed
  127. Diabetes. 2003 Mar;52(3):614-20 - PubMed
  128. Mol Metab. 2014 Aug 13;3(7):754-69 - PubMed
  129. Circulation. 2016 Feb 23;133(8):698-705 - PubMed
  130. J Mol Cell Cardiol. 2006 Aug;41(2):340-9 - PubMed
  131. Circ Res. 2012 Aug 17;111(5):628-41 - PubMed
  132. Circ Res. 2017 Sep 15;121(7):711-721 - PubMed
  133. J Mol Cell Cardiol. 2014 Sep;74:251-9 - PubMed
  134. Life Sci. 2013 Mar 28;92(11):609-15 - PubMed
  135. J Biol Chem. 2014 Jun 13;289(24):16615-23 - PubMed
  136. PLoS One. 2016 Mar 25;11(3):e0151802 - PubMed
  137. Circulation. 2001 Dec 11;104(24):2996-3007 - PubMed
  138. Diabetes. 2006 Feb;55(2):466-73 - PubMed
  139. Circ Res. 2017 Sep 15;121(7):838-854 - PubMed
  140. Circ Res. 2005 Aug 19;97(4):372-9 - PubMed
  141. Circulation. 2002 Jul 30;106(5):606-12 - PubMed
  142. Biochim Biophys Acta. 2016 Oct;1861(10):1555-68 - PubMed
  143. JACC Basic Transl Sci. 2018 Aug 26;3(5):575-587 - PubMed
  144. Endocrinology. 2005 Dec;146(12):5341-9 - PubMed
  145. Circulation. 2004 May 11;109(18):2191-6 - PubMed
  146. Can J Cardiol. 2020 Mar 8;: - PubMed
  147. Biochem Biophys Res Commun. 2001 Sep 21;287(2):391-6 - PubMed
  148. Life Sci. 2013 Mar 28;92(11):633-8 - PubMed
  149. Metabolism. 2017 Dec;77:65-72 - PubMed
  150. Am J Physiol Endocrinol Metab. 2010 May;298(5):E1049-57 - PubMed
  151. Am J Physiol Heart Circ Physiol. 2015 Mar 1;308(5):H467-77 - PubMed
  152. J Clin Invest. 2007 Oct;117(10):2791-801 - PubMed
  153. Cardiovasc Res. 2004 Oct 1;64(1):3-5 - PubMed
  154. Mol Cell Biochem. 2008 Apr;311(1-2):215-24 - PubMed

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