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Pizzo F, Lombardo A, Manganaro A, et al. A New Structure-Activity Relationship (SAR) Model for Predicting Drug-Induced Liver Injury, Based on Statistical and Expert-Based Structural Alerts. Front Pharmacol. 2016;7:442doi: 10.3389/fphar.2016.00442.
Pizzo, F., Lombardo, A., Manganaro, A., & Benfenati, E. (2016). A New Structure-Activity Relationship (SAR) Model for Predicting Drug-Induced Liver Injury, Based on Statistical and Expert-Based Structural Alerts. Frontiers in pharmacology, 7442. https://doi.org/10.3389/fphar.2016.00442
Pizzo, Fabiola, et al. "A New Structure-Activity Relationship (SAR) Model for Predicting Drug-Induced Liver Injury, Based on Statistical and Expert-Based Structural Alerts." Frontiers in pharmacology vol. 7 (2016): 442. doi: https://doi.org/10.3389/fphar.2016.00442
Pizzo F, Lombardo A, Manganaro A, Benfenati E. A New Structure-Activity Relationship (SAR) Model for Predicting Drug-Induced Liver Injury, Based on Statistical and Expert-Based Structural Alerts. Front Pharmacol. 2016 Nov 22;7:442. doi: 10.3389/fphar.2016.00442. eCollection 2016. PMID: 27920722; PMCID: PMC5118449.
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Front Pharmacol. 2016 Nov 22;7:442. doi: 10.3389/fphar.2016.00442. eCollection 2016.

A New Structure-Activity Relationship (SAR) Model for Predicting Drug-Induced Liver Injury, Based on Statistical and Expert-Based Structural Alerts.

Frontiers in pharmacology

Fabiola Pizzo, Anna Lombardo, Alberto Manganaro, Emilio Benfenati

Affiliations

  1. Department of Environmental Health Sciences, IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri" Milan, Italy.

PMID: 27920722 PMCID: PMC5118449 DOI: 10.3389/fphar.2016.00442

Abstract

The prompt identification of chemical molecules with potential effects on liver may help in drug discovery and in raising the levels of protection for human health. Besides

Keywords: chemical clustering; drugs; hepatotoxicity; structural alerts; structure-activity relationship

References

  1. Toxicol Appl Pharmacol. 2007 Apr 1;220(1):92-107 - PubMed
  2. Clin Liver Dis. 2013 Nov;17 (4):671-86, ix-x - PubMed
  3. Eur J Clin Pharmacol. 2010 Oct;66(10 ):961-76 - PubMed
  4. J Pediatr. 1976 Nov;89(5):835-8 - PubMed
  5. Curr Drug Discov Technol. 2004 Dec;1(4):243-54 - PubMed
  6. Clin Chem. 2005 Oct;51(10 ):1796-803 - PubMed
  7. Biomark Med. 2014;8(2):201-13 - PubMed
  8. Expert Opin Drug Deliv. 2007 Sep;4(5):513-31 - PubMed
  9. AAPS J. 2006 Feb 03;8(1):E20-6 - PubMed
  10. Toxicology. 2008 Mar 20;245(3):194-205 - PubMed
  11. J Clin Pharmacol. 1990 May;30(5):396-403 - PubMed
  12. Drug Discov Today. 2007 Sep;12(17-18):777-85 - PubMed
  13. J Pediatr Gastroenterol Nutr. 2008 Oct;47(4):395-405 - PubMed
  14. Bioinformatics. 2011 Jul 1;27(13):i205-13 - PubMed
  15. Ther Clin Risk Manag. 2007 Dec;3(6):1153-63 - PubMed
  16. Chem Res Toxicol. 2010 Jul 19;23 (7):1215-22 - PubMed
  17. Clin Liver Dis. 2009 May;13(2):277-94 - PubMed
  18. Toxicol Appl Pharmacol. 2009 Dec 15;241(3):356-70 - PubMed
  19. Toxicol Appl Pharmacol. 1996 Jul;139(1):186-94 - PubMed
  20. Pharmacopsychiatry. 1990 Jan;23(1):56-7 - PubMed
  21. J Pharmacokinet Pharmacodyn. 2012 Oct;39(5):527-41 - PubMed
  22. Chem Biodivers. 2009 Nov;6(11):2107-14 - PubMed
  23. CMAJ. 2012 Oct 2;184(14 ):1565-70 - PubMed
  24. Chemosphere. 2014 Aug;108:10-6 - PubMed
  25. BMJ. 1993 Jan 23;306(6872):233-5 - PubMed
  26. Chem Cent J. 2015 Nov 05;9:62 - PubMed
  27. Clin Gastroenterol Hepatol. 2011 Jun;9(6):517-523.e3 - PubMed
  28. Am J Otolaryngol. 2007 Jan-Feb;28(1):28-30 - PubMed
  29. AAPS J. 2006 Feb 03;8(1):E48-54 - PubMed
  30. Chem Res Toxicol. 2015 Jul 20;28(7):1391-7 - PubMed
  31. J Hepatol. 2006;44(1 Suppl):S132-9 - PubMed
  32. SAR QSAR Environ Res. 2013;24(5):365-83 - PubMed
  33. Toxicol Sci. 2013 Nov;136(1):242-9 - PubMed
  34. Toxicol Sci. 2005 Feb;83(2):282-92 - PubMed
  35. Pharmacopsychiatry. 1996 Mar;29(2):79-80 - PubMed
  36. J Appl Toxicol. 2015 Feb;35(2):165-72 - PubMed
  37. Curr Med Chem. 2009;16(23 ):3041-53 - PubMed
  38. Drug Discov Today. 2011 Aug;16(15-16):697-703 - PubMed
  39. Cancer Chemother Pharmacol. 2009 Feb;63(3):477-89 - PubMed
  40. Toxicol Appl Pharmacol. 2009 Aug 15;239(1):21-8 - PubMed
  41. Br J Clin Pharmacol. 2004 Jul;58(1):71-80 - PubMed
  42. Environ Health Perspect. 2001 Mar;109 Suppl 1:69-75 - PubMed
  43. J Clin Invest. 2005 Feb;115(2):209-18 - PubMed
  44. Expert Rev Gastroenterol Hepatol. 2014 Sep;8(7):721-3 - PubMed
  45. Gut. 1986 Jun;27(6):726-7 - PubMed
  46. Food Chem Toxicol. 2007 Sep;45(9):1551-7 - PubMed
  47. Oncologist. 2001;6(2):162-76 - PubMed
  48. Crit Rev Toxicol. 2013 Aug;43(7):537-58 - PubMed
  49. Pharmacol Res. 2004 May;49(5):481-6 - PubMed
  50. Am J Clin Nutr. 2006 Feb;83(2):191-201 - PubMed
  51. Am J Clin Nutr. 2003 Dec;78(6):1152-9 - PubMed
  52. Crit Rev Toxicol. 2005 Apr-May;35(4):325-61 - PubMed
  53. J Cheminform. 2014 Oct 18;6(1):39 - PubMed
  54. J Antimicrob Chemother. 2001 Oct;48(4):463-78 - PubMed
  55. Drug Discov Today Technol. 2004 Dec;1(4):381-7 - PubMed
  56. Drug Saf. 1999 Nov;21(5):407-21 - PubMed
  57. Hepatology. 2011 Apr;53(4):1377-87 - PubMed
  58. Toxicol Lett. 2009 Apr 10;186(1):22-31 - PubMed
  59. Clin Liver Dis. 2007 Aug;11(3):549-61, vi - PubMed
  60. Clin Chem. 2009 Nov;55(11):1977-83 - PubMed
  61. Drugs. 2001;61(7):919-42 - PubMed
  62. J Clin Psychiatry. 1978 Sep;39(9):730-1 - PubMed
  63. Am J Otolaryngol. 1995 May-Jun;16(3):153-7 - PubMed
  64. Anesth Analg. 1989 Jun;68(6):734-9 - PubMed
  65. Eur J Clin Pharmacol. 1995;49(1-2):81-5 - PubMed
  66. Expert Opin Drug Saf. 2003 May;2(3):249-62 - PubMed
  67. Drug Discov Today. 2008 Apr;13(7-8):303-10 - PubMed
  68. Drug Discov Today. 2003 Nov 15;8(22):1044-50 - PubMed
  69. Ann Pharmacother. 2007 Jul;41(7):1201-11 - PubMed
  70. Chem Res Toxicol. 2010 Jan;23 (1):171-83 - PubMed
  71. Expert Opin Drug Metab Toxicol. 2012 Feb;8(2):201-17 - PubMed
  72. Chem Biol Interact. 1995 Oct 20;98(1):85-95 - PubMed
  73. Drugs. 1999;58 Suppl 2:37-42 - PubMed
  74. Curr Allergy Asthma Rep. 2007 Apr;7(1):41-8 - PubMed
  75. Eur J Gastroenterol Hepatol. 1995 Apr;7(4):373-6 - PubMed
  76. J Clin Psychopharmacol. 1983 Aug;3(4):243-6 - PubMed
  77. Am J Clin Pathol. 2004 Mar;121(3):324-9 - PubMed
  78. Mol Inform. 2016 Apr;35(3-4):136-44 - PubMed
  79. Hepatology. 1999 May;29(5):1347-51 - PubMed
  80. J Gastroenterol Hepatol. 1990 May-Jun;5(3):334-42 - PubMed
  81. J Comput Aided Mol Des. 2003 Dec;17(12):811-23 - PubMed
  82. Toxicol Pathol. 1997 Jan-Feb;25(1):53-60 - PubMed

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