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Dawson KA, Boling JA. Effects of potassium ion concentrations on the antimicrobial activities of ionophores against ruminal anaerobes. Appl Environ Microbiol. 1987;53(10):2363-7doi: 10.1128/aem.53.10.2363-2367.1987.
Dawson, K. A., & Boling, J. A. (1987). Effects of potassium ion concentrations on the antimicrobial activities of ionophores against ruminal anaerobes. Applied and environmental microbiology, 53(10), 2363-7. https://doi.org/10.1128/aem.53.10.2363-2367.1987
Dawson, K A, and Boling, J A. "Effects of potassium ion concentrations on the antimicrobial activities of ionophores against ruminal anaerobes." Applied and environmental microbiology vol. 53,10 (1987): 2363-7. doi: https://doi.org/10.1128/aem.53.10.2363-2367.1987
Dawson KA, Boling JA. Effects of potassium ion concentrations on the antimicrobial activities of ionophores against ruminal anaerobes. Appl Environ Microbiol. 1987 Oct;53(10):2363-7. doi: 10.1128/aem.53.10.2363-2367.1987. PMID: 3426214; PMCID: PMC204113.
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Atypon Free PMC Article

Appl Environ Microbiol. 1987 Oct;53(10):2363-7. doi: 10.1128/aem.53.10.2363-2367.1987.

Effects of potassium ion concentrations on the antimicrobial activities of ionophores against ruminal anaerobes.

Applied and environmental microbiology

K A Dawson, J A Boling

Affiliations

  1. Department of Animal Sciences, University of Kentucky, Lexington 40546-0215.

PMID: 3426214 PMCID: PMC204113 DOI: 10.1128/aem.53.10.2363-2367.1987
Free PMC Article

Abstract

The antimicrobial activities of monensin and lasalocid against representative strains of ruminal bacteria were evaluated in medium containing three different concentrations of potassium (1.3, 7.9, or 23.3 mM). The growth of Eubacterium ruminantium was inhibited by low concentrations of ionophores (less than or equal to 0.16 mg/liter), while the strain of Streptococcus bovis tested was resistant to high concentrations of ionophores (40 mg/liter) at all potassium concentrations tested. The MICs of the ionophores for strains of Bacteroides succinogenes, Butyrivibrio fibrisolvens, Ruminococcus albus, and Ruminococcus flavefaciens and for one strain of Bacteroides ruminicola increased with increasing potassium concentrations in the medium. High concentrations of ionophores (40 mg/liter) decreased the maximum cell yields or increased the lag times or both in cultures of one strain of Bacteroides ruminicola and two strains of Selenomonas ruminantium but did not completely inhibit the growth of these organisms. Increased potassium concentrations in the medium (from 7.9 to 23.3 mM) decreased the lag times or increased the cell yields or both when these three strains were grown in ionophore-containing medium, while the activities of lasalocid and monensin against these organisms were enhanced in the medium containing low potassium concentrations (1.3 mM). The data from this study suggest that extracellular potassium concentrations may influence the antimicrobial activities of ionophores in the rumen.

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